Effects of a κ-Receptor Agonist U-50488 on Bulbar Respiratory Neurons and Its Antagonistic Action Against the μ Receptor-Induced Respiratory Depression in Decerebrate Cats
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概要
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The function of κ receptor-mechanisms in bulbar respiratory network was investigated in decerebrate cats. Intravenous injection of U-50488 (0.3 – 3.0 mg/kg) dose-dependently decreased the phrenic nerve discharge and shortened inspiration and expiration. U-50488 caused hyperpolarization, and decreased input resistance and the action potential discharge in respiratory neurons. The effects of U-50488 were antagonized by nor-binaltorphimine. DAMGO (0.3 mg/kg, i.v.) decreased the phrenic discharge and prolonged inspiration and expiration. U-50488 partially reversed the respiratory depression induced by DAMGO. These results suggest that the activation of κ receptors by itself depresses the central respiratory activity, while it opposes the μ receptor-mediated respiratory depression.
- 社団法人 日本薬理学会の論文
- 2001-12-01
著者
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Haji Akira
Department Of Pharmacology Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Haji A
Department Of Pharmacology Faculty Of Medicine Toyama Medical And Pharmaceutical University
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TAKEDA Ryuji
Department of Pharmacology, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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Takeda R
Department Of Pharmacology Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Takeda Ryuji
Department Of Orthopedic And Musculoskeletal Surgery Graduate School Of Medicine Kyoto University
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