静脈性嗅覚検査の基礎的研究 : 呼気中嗅素濃度について

概要

論文の詳細を見る
The intravenous olfaction test with Alinamin is a simple procedure and widely used. However, fundamentals on the test are still obscure in many respects.In the present study we measured changes with time in concentrations of an odorous substance in the expired air during the test.Measurement was made of concentrations of the odorous substance in the expired air after intravenous injection of Alinamin by subjecting a sulfur compound contained in Alinamin or its detritus to the gas chromatograph (Shimazu GC-6A). The results obtained were as follows.1) Alinamin was not detected in the expired air after intravenous injection of Alinamin. However, a product of decomposition of Alinamin was observed.2) Measurement was made of concentrations of this product with time. As a result, it was observed 20 seconds after initiation of the intravenous injection, reached its peak 40-60 seconds later and then decreased gradually.3) This product was identified as N-propyl mercaptan.4) We were able to learn changes with time in concentration of N-propyl mercaptan in the expired air after intravenous injection of Alinamin.
社団法人日本耳鼻咽喉科学会の論文