中耳粘膜上皮の発生学的研究 : 電子顕微鏡による

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Middle ear mucosae of 56 fetal and 90 young rats were investigated with SEM, TEM andserial sections for light microscope for the purpose of obtaining a better understanding of the fine structure of middle ear mucosa.The results of this study showed that secretory cells interspersed with ciliated cells were predominantly distributed around the tympanic orifice and transitionl zone.In general, the cellular distribution pattern between suckling rats and adult rats was similar, even though the distribution of ciliated and secretory cells varied to a certain extent from one adult to another.It was also evidenced that(1) light and dark secretory granules appeared in the Golgi area of some epithelial cells in 17 to 20 fetal day and that(2) primary cilla and immature cilia were seen from 16 to 17 fetal day in the transitional zone near the tympanic orifice.The number of ciliated and secretory cells increased rapidly after birth.It was failed to find glands in the osseous tube, tympanic orifice and other portion of the middle ear cavity in fetal, newborn and suckling rats, while there existed abundant glands in the cartilaginous portion of the tube.Secretory modes of Kurosumis extrusion type II, 111, IV and V could be observed.The most common secretory cells were mucous cells with light secretory granules, showing eccrine secretion(type IV).The less common cells were the mixed granulated cells with apocrine secretion(type II and III).The liest was the dark granulated cells with eccrine secretion(type V).The distinction between light granulated and dark granulated cells was able to establish at 20 fetal day.Findings of this study indicate that both secretory and ciliated cells are normal components of middle ear mucosa although these cells are restricted within the tympanic orifice and transitional zone, and that the mucociliary defense system starts to develop at the fetal stage
社団法人日本耳鼻咽喉科学会の論文

中耳粘膜上皮の発生学的研究 : 電子顕微鏡による

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