筋肉の動き

概要

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The molecular and submolecular mechanism of muscle contraction was surveyed from a crystallographic point of view.<BR>The contraction is a result of interactions of two kinds of myofilamants, thick and thin filaments, which are the assemblies of hundreds of myosin and actin molecules, respectively. No conspicuous intramolecular conformational change associated with contraction can be found by X-ray diffraction analysis. What can be detected on contraction is the change in steric relationship between both kinds of filaments. The merits and demerits of electron microscopic and X-ray diffraction techniques in analyzing such changes are discussed. Recent new findings using the technique to reconstruct the three-dimensional structure of such filaments from the electron microscopic images by Fourier transform and synthesis are referred to.
日本結晶学会の論文