CEA-doubling Time and Clinicopathological Future in Colorectal Cancer.

概要

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Although the CEA-doubling time directly associated with the tumor growth of colorectal cancer, and it was rated as an index of the tumor growth, it was hardly obtained at the time of the primary operation. In order to find the factors in clinicopathological findings, which correlate with CEA-doubling time 60 of 538 cases operated colorectal cancer cases were analized in the study. All cases confirmed an r>0.8 correlation between the value of log-CEA and post operative days. The two-tailed unpaired T-test was used to assess the assay for each factor. There was no relationship between clinicopathological findings and CEA-doubling time. Furthermore, the CEA-doubling time was not correlated with a period of days between surgery and the start of the CEA rising. These studies strongly suggest that a clinicopathological future is not affected by CEA-doubling time. Therefore, the CEA-doubling time is a peculiar factor of the prognostic index of the colorectal cancer in the period after the CEA rises exponently above the normal range.
日本大腸肛門病学会の論文