大腸胃重複癌の臨床病理学的検討

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Between January 1965 and June 1991, we encountered 32 cases of overlapping gastric cancer from a total of 875 cases (3.7%) of colon cancer: 825 surgical cases and 50 endoscopic polypectomy ones. Breakdown was 13 synchronous cases and 19 metachronous cases.<BR>Comparison with the controls-843 cases of colon cancer without overlapping gastric cancer-showed that the 32 overlapping cases were conspicuous in the following respects: Males far outnumbered females, 30 to 2 (p<0.01). As many as 5 cases had positive family histories (CCFH*(+) ; p<0.01). Right-side colon cancer was predominant, present in 14 cases (43.8% ; p<0.01). Advanced colon cancer combined with early gastric cancer claimed a total of 20 cases-the greatest portion, and early cancer in the stomach occurred more frequently than in the cases of gastric cancer encountered during the same period (p<0.01).<BR>Colon cancer with hepatic metastasis was the cause of death in 4 of the synchronous cases, and other diseases were accountable for death in 2 cases. Second cancer was the primary cause of death in the metachronous cases. As nearly half of the metachronous patients developed the second cancer between 5 to 15 years of surgery for the first, long-term followup of the first cancer and long-term surveillance of possible second cancer seemed to be warranted.<BR>*Colorectal cancer occurring in one or more family members among their first-degree relatives
日本大腸肛門病学会の論文