Clinicopathological study on poorly differentiated colorectal carcinoma.

概要

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The clinicopathological features of 20 cases of poorly differentiated adencarcinoma of the colon and rectum resected in the authors' department from 1978 to 1988 were compared with those of 222 well and moderately differentiated cases. The incidence of poorly differentiated adenocarcinoma was 7.7 %, and the site was often the right colon of C+A (p<0.01). None of the cases were early cancer, and the maximum diameter of the tumor was at least 3.1 cm in all cases. The positive rate for lymph node mateastatis was high at 75 %, and the degree of deep wall penetration was at least SS (a<SUB>1</SUB>) in all cases. The histological stage was stage II in three cases (15 %), stage III in seven cases (35 %), stage IV in two cases (10 %) and stage V in eight cases (40 %) ; most cases were highly advanced. Curative operations were performed in only nine cases, and four of these cases have survived for at least 5 years. Poorly differentiated adenocarcinomas are already in the advanced stage and most patients undergo operations. Cases of long-term survival are achieved by performing extended operations.
日本大腸肛門病学会の論文