Clinicopathological studies on the evolution and development of large bowel carcinoma.

概要

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32 early carcinomas of the human large bowel and 34 large bowel tumors experimentally induced in rats were histopathologically studied. 21 of human carcinomas were seen with adenoma. Every one of these 21 appeared as an elevated lesion. The tumors with the diameter less than 2cm were carcinoma in situ. The larger the diameter of the tumor measured, the deeper the tumor invaded in human carcinomas with adenoma. Eleven of human carcinomas were seen without adenoma. Three of these were depressed type. There was not an evident relationship between the macroscopic findings and the depth of invasion in the human carcinoma without adenoma. It was contrary to the relationship between the diameter and the depth of invasion of the carcinomas with adenoma, that the tumor with the diameter less than 2cm showed submucosal cancer invasion in carcinomas without adenoma. All of the 34 tumors, which were experimentally induced in rats, were elevated type. 18 of these were carcinoma. While the tumors of those 34 with smaller diameter were adenomas, those with larger diameter were carcinomas. Among these, nothing showed coexsistence of carcinoma and adenoma. Our observation suggested that early carcinoma without adenoma in human large bowel and experimentally induced large bowel carcinomas be de novo carcinoma.
日本大腸肛門病学会の論文