Observasion of surface structure of colonic villouss tumor and analysis on its growth pattern.

概要

論文の詳細を見る
From 1978 to 1987, the authors have experienced 50 lesions of the villous tumor in 38 cases. Firstly, the surface structure of the tumor was observed by the magnifying endoscope and stereoscopic microscope. The evidence of carcinoma and its localization were investigated histologically in order to study the growth pattern of the villous tumor. Secondary in order to study the histogenesis of villous adenoma, and to analyze the malignant potentiality of this tumor, the S-phase cell were labelled by the ex vivo autoradiogram by perfusing the resected specimien with oxygenated perfluorochemicals supplemented with tritium thymidine. Results are as follows :(1)Ex vivo labelling method revealed the uniform diffuse distribution of S-phase cells in villous adenoma, in comparison to the tubular adenoma approximetely same size which showed compartmentalization.(2)Villous adenoma showed strong tendency to grow in both lateral and upward directions.(3)The labelling index of villous adenoma was greater than that of tubular adenoma and was smaller than that of adenocarcinoma.(4)Result of ex vivo autoradiogram suggest the malignant potentiality of this tumor developing multi focal carcinoma. When focal cancers develope in the deep crypt, it is rather difficult to identify the lesion from the surface.
日本大腸肛門病学会の論文