Expression of Vascular Endothelial Growth Factor in Pulmonary Aspergilloma.
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概要
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Objective Vascular endothelial growth factor (VEGF), a cytokine associated with malignant neoplasms, is increased in a number of inflammatory and infectious disorders. But little is known about VEGF in pulmonary aspergilloma (PA). In order to clarify the predictive value of VEGF in PA, we examined serum VEGF levels in PA patients as well as expression of VEGF in the PA lesion. Patients Twenty-one patients with PA (6 with hemoptysis and the rest without hemoptysis) were investigated. Methods In all patients, serum VEGF levels were measured by enzyme-linked immunosorbent assay. We examined the statistical correlations of serum VEGF levels with the ratio of affected area to total lung volume and VEGF with PaO2 levels. In patients with hemoptysis, we measured the serum VEGF levels three months after the initiation of therapy. We examined the expression of VEGF in the resected lung tissue of 4 patients with PA using immunohistochemistry. Results Serum VEGF levels showed a significant positive correlation with the ratio of affected to total lung area and a significant negative correlation with PaO2 levels. Serum VEGF levels in patients with hemoptysis were significantly higher than in those without hemoptysis. The serum levels of VEGF in patients with hemoptysis decreased significantly in parallel with the alleviation of hemoptysis. Immunohistochemical staining demonstrated the expression of VEGF in alveolar macrophages in the lesion of PA patients. Conclusion We suggest that VEGF can be used as a serum marker to determine the extent of the lesion, hypoxia and hemoptysis in PA.(Internal Medicine 40: 1195-1199, 2001)
- 社団法人 日本内科学会の論文
著者
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HASHIGUCHI Teruto
the Third Department of Internal Medicine, Kagoshima University
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KAWABATA Masaharu
the Third Department of Internal Medicine, Kagoshima University
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WAKIMOTO Joeji
the Department of Respiratory Medicine, National Minami-kyushu Hospital
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HIROTSU Yasunobu
the Department of Thoracic Surgery, National Minami-Kyushu Hospital
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Arimura Kimiyoshi
The Third Department Of Internal Medicine School Of Medicine Kagoshima University
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MATSUYAMA Wataru
the Third Department of Medicine, Kagoshima University School of Medicine
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Kawabata Masaharu
The Third Department Of Internal Medicine Kagaoshima University School Of Medicine
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Osame Mitsuhiro
The Third Department Of Internal Medicine Faculty Of Medicine
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Wakimoto Joeji
the Department of Raspiratory Medicine, National Minami-Kyushu Hospital
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ARIMURA Kimiyoshi
The Third Department of Internal Medicine, Kagoshima University
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INOUE Koji
the Third Department of Internal Medicine, Kagoshima University
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MATSUYAMA Wataru
the Third Department of Internal Medicine, Kagoshima University
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