Pressor Response in Essential Hypertension : Blood Pressure Response to Noradrenaline in the Patient with Essential Hypertension
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概要
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In order to evaluate the pressor response to noradrenaline by using a simple procedure, experiments were carried out on 127 normotensive subjects and 125 patients with essential hypertension. When the blood pressure had reached a constant level, l-noradrenaline (5μg./Kg. of body weight) was injected intramuscularly. The blood pressure was measured every 30 or 60sec. by the auscultatory method until the pressure returned to the base line.A significant increase of pressor response in the hypertensive patients was demonstrated by the higher and prolonged pressure curve than in the normotensive subjects. While the pressor response in the normotensive was independent on the age, that in the hypertensive was more remarkable in the younger age group. In accordance with this, a positive correlation between the basal pressure and the pressure rise was more significant in the younger subjects. In both normotensives and hypertensives, the subjects whose one or both parents were hypertensive showed significantly greater increase of pressor response than those who had no hypertensive paitents. The patients with progressed retinal change tended to have less pronounced pressor response, irrespective of the age.It may be concluded from these results that 1) by using a simple method, the increased vascular reactivity to noradrenaline in essential hypertension can be demonstrated statistically despite a considerable overlapping, 2) the structural change in the vessels does not appear to play an important role for the increased reactivity, 3) this hyper-reactivity in which a hereditary factor is participated, is an initiating cause of essential hypertension, and 4) in the late or advanced phase of this disease, the increased response becomes less remarkable.
- International Heart Journal刊行会の論文
著者
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UEDA TADASHI
Department of Pediatrics, Faculty of Medicine, Kyoto University
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IIMURA OSAMU
Department of Nephrology, Jichi Medical School
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Miyahara Mitsuo
The Second Department Of Internal Medicine Sapporo Medical College
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Ueda Tadashi
Department Of Anatomy
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Miyahara Mitsuo
Depart Nent Of Inlernal Medicine (seclion Ii) Sapporo Medical College
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Iimura Osamu
Depart Nent Of Inlernal Medicine (seclion Ii) Sapporo Medical College
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Mori Masaki
Division Of Gene Therapy Science Osaka University
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Miyahara M.
Department Of Internal Medicine Sapporo Medical College
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IIMURA Osamu
Department of Internal Medicine, Sapporo Medical College
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