Influence of Exercise on QT Dispersion in Ischemic Heart Disease.
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概要
- 論文の詳細を見る
QT dispersion (QTd: maximum QT interval-minimum QT interval) is associated with severe cardiac arrhythmia and with abnormal ventricular repolarization. We investigated the influence of exercise on QTd in patients with ischemic heart disease. On standard 12-lead electrocardiograms, QTd was measured before and after treadmill exercise in 7 normal subjects, 17 patients with effort angina pectoris (and_??_75% stenosis on coronary arteriography), and 33 patients with old myocardial infarction. Bazett's formula was used to obtain the corrected QTd (QTcd). The pre-exercise resting QTcd was 45.9±10.6, 44.3±15.2, and 74.8±28.1msec in the respective groups, being significantly greater in the infarct group (p<0.05). The QTcd at 5min after exercise was respectively 49.3±9.0, 58.8±19.9, and 75.4±30.9msec (p=0.0347, infarct vs. controls). The difference in QTcd was significant for the angina group before and after physical exercise (p=0.0003). There was a significant increase of QTcd after exercise in the angina group whether or not the patients were receiving β-blockers. The infarct patients without β-blocker therapy showed an increase of QTcd after exercise, while those receiving β-blockers showed a decrease. The past-exercise difference between these subgroups was significant (p=0.0351). Conclusions: QTcd was significandy increased by exercise in the angina group, possibly reflecting impaired repolarization due to ischemia. Inhibition of the increase in QTd by β-blockers suggested a possible preventive effect on severe arrhythmias due to nonhomogeneous ventricular repolarization.
- International Heart Journal刊行会の論文
著者
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Nagashima Junzo
Department Of Cardiology St. Marianna University Yokohama City Seibu Hospital
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Takada Hideomi
The Second Dept. of Internal Medicine, St.Marianna University, School of Medicine
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Murayama Masahiro
The Second Department Of Internal Medicine Faculty Of Medicine
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Nakamura Toshika
Department Of Cardiology St. Marianna University School Of Medicine
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Musha Haruki
Department Of Cardiology St. Marianna University School Of Medicine
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Kunishima Tomoyuki
Department Of Cardiology St. Marianna University School Of Medicine
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OOBA Haruo
The Second Department of Internal Medicine, St. Marianna University, School of Medicine
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NAGASHIMA Junzo
Department of Cardiology, Yokohama-city Seibu Hospital, St. Marianna University, School of Medicine
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KUNISHIMA Tomoyuki
Department of Cardiology, Yokohama-city Seibu Hospital, St. Marianna University, School of Medicine
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NAKAMURA Toshika
Department of Cardiology, Yokohama-city Seibu Hospital, St. Marianna University, School of Medicine
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AWAYA Toru
Department of Cardiology, Yokohama-city Seibu Hospital, St. Marianna University, School of Medicine
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IWASAKI Tatsuya
Department of Cardiology, Yokohama-city Seibu Hospital, St. Marianna University, School of Medicine
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MURAYAMA Masahiro
The Second Department of Internal Medicine, St. Marianna University, School of Medicine
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OOHAMA Nagatoshi
Department of Cardiology, Yokohama-city Seibu Hospital, St. Marianna University, School of Medicine
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ARAI Satoshi
The Second Department of Internal Medicine, St. Marianna University, School of Medicine
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TAKADA Hideomi
The Second Department of Internal Medicine, St Marianna University, School of Medicine
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MUSHA Haruki
Department of Cardiology, Yokohama-city Seibu Hospital, St. Marianna University, School of Medicine
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