Severity of Myocardial Fatty Acid Dysmetabolism Induced by Coronary Spasm Does not Differ With Thrombolysis in Myocardial Infarction (TIMI) Grade During Intracoronary Acetylcholine Provocation Tests
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概要
- 論文の詳細を見る
Whether additional intracoronary acetylcholine (ACH) injections are required for severe coronary spasm without limited coronary flow in the ACH provocation test remains unclear. We used 123I-β-methyl-iodophenyl pentadecanoic acid (123I-BMIPP) to identify myocardial ischemic memory to compare the severity of myocardial fatty acid dysmetabolism among Thrombolysis in Myocardial Infarction (TIMI) grade flow.Thirteen hypertensive volunteers (mean age, 69.5 years) and 37 patients with VSA (mean age, 62.8 years) were enrolled. The patients with VSA were stratified according to TIMI flow grades of 3 (90% luminal narrowing; n = 12) or TIMI 0-2 (≥ 99% or total occlusion; n = 25) during ACH provocation tests. Two weeks after cardiac catheterization, 123I-BMIPP myocardial scintigraphic images were obtained at 15 minutes (early) and at 4 hours (delayed) after tracer injection. The heart-to-mediastinum (H/M) ratio and washout rates (WR) were calculated from planar images.The TIMI 3 and TIMI 0-2 groups had significantly lower early and delayed H/M ratios than controls but the difference did not reach significance between the two groups (Early: 2.7 ± 0.5 versus 2.3 ± 0.4 and 2.2 ± 0.3, P = 0.024; Delayed: 2.4 ± 0.4 versus 1.8 ± 0.3 and 1.8 ± 0.3, P = 0.001). The washout rate was greater for TIMI 0-2 than the controls.The severity of myocardial fatty acid dysmetabolism did not differ between TIMI 3 and TIMI 0-2 coronary spasms. Additional ACH might not be required considering safety and the severity of coronary spams with TIMI 3 grade flow.
- 一般社団法人 インターナショナル・ハート・ジャーナル刊行会の論文
著者
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SUZUKI Kengo
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine
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Suzuki Kengo
Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine
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Yoneyama Kihei
Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine
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Akashi Yoshihiro
Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine
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Sato Yukio
Division Of Accelerator Physics And Engineering National Institute Of Radiological Sciences
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Kida Keisuke
Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine
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Musha Haruki
Department Of Cardiology St. Marianna University School Of Medicine
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Takagi Yasushi
Division Of Cardiology Fujita Health University Hospital
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ASHIKAGA Kohei
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine
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Harada Tomoo
Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine
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Kamijima Ryo
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine
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Tsukahara Maya
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine
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Yamada Marika
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine
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