A New Approach to the Development of Anti-ischemic Drugs. Substances that Counteract the Deleterious Effect of Lysophosphatidylcholine on the Heart.:Substances that Counteract the Deleterious Effect of Lysophosphatidylcholine on the Heart
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概要
- 論文の詳細を見る
Lysophosphatidylcholine (LPC) is an amphiphilic metabolite that can be produced from membrane-phospholipids by activation of phospholipase A2 (PLA2), and it accumulates in the heart during ischemia and reperfusion. It is known that LPC is an arrhythmogenic substance. Recent studies have revealed that LPC produces mechanical and metabolic derangements in perfused working rat hearts, and Ca2+-overload in isolated cardiac myocytes. Thus, LPC possesses an ischemia-like effect on the heart. LPC accumulated in the myocardium activates phospholipase A2, establishing a vicious circle; i.e. LPC itself has an ability to produce another LPC. Therefore, a drug that has an anti-LPC effect would protect or improve ischemia/reperfusion damage. This article will review the effect of LPC in relation to ischemia, and consider a possibility of developing new anti-ischemic drugs on the basis of the anti-LPC action.
- International Heart Journal刊行会の論文
著者
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Hara Akiyoshi
Department of Pharmacology, Asahikawa Medical College
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Hara Akiyoshi
Department Of Pharmacology Asahikawa Medical College
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Magishi Katsuaki
Department Of Cardiovascular Surgery Nayoro City General Hospital
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Abiko Yasushi
Department Of Pharmacology
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Hashizume Hiroko
Department Of Pharmacology Asahika Wa Medical College
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HASHIZUME Hiroko
Department of Pharmacology, Asahikawa Medical College
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HOQUE Ehsanul
Department of Pharmacology and Toxicology, University of Western Ontario
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