Evaluation of Left Ventricular Diastolic Hemodynamics from the Left Ventricular Inflow and Pulmonary Venous Flow Velocities in Hypertrophic Cardiomyopathy.

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概要

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• We evaluated the characteristics of left ventricular diastolic hemodynamics in hypertrophic cardiomyopathy (HCM) by measuring left ventricular inflow (LVIF) and pulmonary venous flow (PVF) velocities in 62 patients with asymmetric septal hypertrophy and 34 normal controls. The patients were divided into four groups according to the LVIF pattern and left ventricular end-diastolic pressure (LVEDP): 1) the pseudonormalization group; 13 patients with the ratio of peak atrial systolic (A) to early diastolic (E) LVIF velocity (A/E) ≤1 and LVEDP ≥15mm Hg, 2) the normal pattern group; 10 patients with the A/E ≤1 and LVEDP <15mm Hg, 3) the relaxation failure group; 25 patients with the A/E >1, and 4) the mid-diastolic wave group; 14 patients with a mid-diastolic wave. The peak early diastolic LVIF velocities in the pseudonormalization, relaxation failure and mid-diastolic wave groups were significantly smaller than in the control group. The deceleration time from the peak of the E wave and the isovolumic relaxation time were significantly prolonged in the relaxation failure and mid-diastolic wave groups. The peak diastolic PVF velocity in the relaxation failure and mid-diastolic wave groups was significantly decreased, and was significantly increased in the pseudonormalization group. The peak atrial systolic PVF velocity was significantly increased in all patients with HCM, particularly in the pseudonormalization group. LVEDP was the highest in the pseudonormalization group, followed by the mid-diastolic wave, relaxation failure and normal pattern groups, in that order. In conclusion, combined analysis of the LVIF and PVF provides useful information regarding various abnormalities of left ventricular diastolic hemodynamics in patients with HCM. (Jpn Heart J 36: 617-627, 1995)

• International Heart Journal刊行会の論文

著者

• Yamada Hirotsugu

  The University of Tokushima Graduate School of Medicine

• Tabata Tomotsugu

  Second Department of Internal Medicine

• Yamada Hirotsugu

  Second Department of Internal Medicine

• Hama Minori

  Second Department Of Internal Medicine School Of Medicine University Of Tokushima

• KIYOSHIGE Koichi

  Second Department of Internal Medicine,University of Tokushima

• IUCHI Arata

  Second Department of Internal Medicine,University of Tokushima

• MANABE Kazuyo

  Second Department of Internal Medicine,University of Tokushima

• KAGEJI Yoshimi

  Second Department of Internal Medicine,University of Tokushima

• FUKUDA Nobuo

  Second Department of Internal Medicine,University of Tokushima

• Sasaki Miwa

  Second Department of Internal Medicine, School of Medicine, University of Tokushima

• Oki Takashi

  Second Department Of Internal Medicine

• Ito Susumu

  Second Department Of Internal Medicine School Of Medicine University Of Tokushima

• KAGEJI Yoshimi

  Second Department of Internal Medicine, Tokushima University School of Medicine

• MANABE Kazuyo

  Second Department of Internal Medicine, School of Medicine, The University of Tokushima

• IUCHI Arata

  Second Department of Internal Medicine, Faculty of Medicine, Tokushima University

• KIYOSHIGE Koichi

  Second Department of Internal Medicine, Tokushima University School of Medicine

• KIYOSHIGE Koichi

  Second Department of Internal Medicine, School of Medicine, University of Tokushima

• SASAKI Miwa

  Second Department of Internal Medicine, Tokushima University School of Medicine

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