Oral Prostaglandin E1 Derivative (OP-1206) in an Infant with Double Outlet Right Ventricle and Pulmonary Stenosis. Effect on Ductus-Dependent Pulmonary Circulation.:Effect on Ductus-Dependent Pulmonary Circulation
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概要
- 論文の詳細を見る
A small-for-gestational-age infant with cyanosis due to double outlet right ventricle with severe pulmonary stenosis and patent ductus arteriosus was treated with oral prostaglandin E1 derivative (OP-1206). The constricting ductus arteriosus dilated and the ductus-dependent pulmonary blood flow increased. The recommended dosage was 1.5-2.0μg/kg/day which was lower than that of intravenous PGE1 or of oral PGE2. The administration interval was 6 hours, which was longer than that of oral PGE2. The patient was treated as an out-patient because continuous intravenous infusion was not necessary. Treatment was continued for 2 months without complication, at which time a Blalock-Taussig shunt operation was performed. Orally administered PGE1 derivative (OP-1206) was found to be equally effective to intravenous infusion of PGE1 for both short and long-term management of cyanotic heart disease in which the pulmonary blood flow is mostly dependent on the patency of the ductus arteriosus. Oral PGE1 derivative (OP-1206) may be a possible substitute for intravenous PGE1 infusion therapy.
- International Heart Journal刊行会の論文
著者
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Matsuura Hiroyuki
Department Of Advanced Materials Science Graduate School Of Frontier Sciences The University Of Toky
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Ishikita Takashi
Department Of Pediatrics Mizonokuchi Hospital Teikyo University School Of Medicine
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Yamamoto Shin
Department Of Cardiothoracic Surgery Juntendo University School Of Medicine
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Saji Tsutomu
Department Of First Department Of Pediatrics Toho University Omori Medical Center
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MATSUO Norio
Department of Pediatric Cardiology, National Children's Hospital
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SAJI Tsutomu
Department of Pediatrics, Toho University
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HOSHINO Kyoko
Department of Pediatrics, Toho University
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ISHIKITA Takashi
Department of Pediatrics, Toho University
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