Autoimmune Thyroid Disease in Children and Adolescents With Idiopathic Pulmonary Arterial Hypertension
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概要
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Background: Previous studies have reported a high prevalence of autoimmune thyroid disease (AITD) in adult patients with pulmonary arterial hypertension (PAH). The aim of this retrospective study was to determine the prevalence of AITD in children and adolescents with idiopathic PAH (IPAH). Methods and Results: The study group included 16 patients who had been diagnosed as having idiopathic PAH when they were younger than 15 years old; all were younger than 20 years of age. Thyroid function and antithyroid antibody levels were examined regularly at 6-12-month intervals and when there were clinical signs of thyroid dysfunction. In total, 7 patients (44%) had AITD; 2 patients developed Graves disease, 2 developed silent thyroiditis, and 3 had antithyroid antibodies with euthyroidism. The duration after PAH onset and the prostacyclin (PGI2) treatment period were significantly longer in patients with AITD (7.6±2.1 and 7.4±2.3 years, respectively) than in patients without AITD (5.0±1.1 and 4.8±1.2 years, respectively; P<0.01 and P<0.05). Conclusions: The prevalence of AITD is high in children and adolescents with IPAH, so evaluation of thyroid function is important to prevent deterioration of right heart failure. (Circ J 2010; 74: 371-374)
- 2010-01-25
著者
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Saji Tsutomu
Department of pediatrics Toho University school of medicine
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MATSUURA Hiroyuki
Department of Physics, Niigata University
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ASO Keiko
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical Universi
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Aso Keiko
Department Of Pediatrics Toho University Omori Medical Center
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Aso Keiko
Department Of Endocrinology And Metabolism Tokyo Metropolitan Kiyose Children's Hospital
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Matsuura Hiroyuki
Department Of Pediatrics Toho University Omori Medical Center
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Matsuura Hiroyuki
Department Of Advanced Materials Science Graduate School Of Frontier Sciences The University Of Toky
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Satoh Mari
Department of Pediatrics, Toho University
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Nakayama Tomotaka
Department of Pediatrics, Toho University Medical Center Omori Hospital
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Satoh Mari
Department Of Pediatrics Toho University Omori Medical Center
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Satoh Mari
Department Of Endocrinology And Metabolism National Children's Medical Research Center
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Saji Tsutomu
Department Of Pediatrics Hospital Of Toho University School Of Medicine
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SHIMADA Hiromitsu
Department of Chemistry, Faculty of Science, Kumanoto University
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NAOI Kazuyuki
Department of Pediatrics, Toho University Omori Medical Center
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IKEHARA Satoshi
Department of Pediatrics, Toho University Omori Medical Center
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UCHINO Yumiko
Department of Pediatrics, Toho University Omori Medical Center
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TAKATSUKI Shinichi
Department of Pediatrics, Toho University Omori Medical Center
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Uchino Yumiko
Department Of Pediatrics Toho University Medical Center Omori Hospital
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Uchino Yumiko
Department Of Pediatrics Toho University Omori Medical Center
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Naoi Kazuyuki
Department Of Pediatrics Toho University Omori Medical Center
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Ikehara Satoshi
Department Of Pediatrics Toho University Omori Medical Center
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Shimada Hiromitsu
Department Of Pediatrics Toho University Omori Medical Center
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Shimada Hiromitsu
Department Of Chemistry Faculty Of Science Kumanoto University
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Takatsuki Shinichi
Department Of Pediatrics Toho University Omori Medical Center
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Nakayama Tomotaka
Department Of Pediatrics Toho University Omori Medical Center
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Nakayama Tomotaka
Department Of Pediatrics Toho University Medical Center Omori Hospital
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Saji Tsutomu
Department Of First Department Of Pediatrics Toho University Omori Medical Center
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Takatsuki Shinichi
Department Of First Department Of Pediatrics Toho University Omori Medical Center
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