Pulmonary arterial pressure and plasma concentration of atrial natriuretic factor (ANF) in patients with heart disease.
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概要
- 論文の詳細を見る
To study the factors controlling the release of atrial natriuretic factor (ANF), we analyzed the peripheral plasma ANF concentration in 34 patients with heart disease who underwent cardiac catheterization.A significant positive correlation between plasma ANF concentration and pulmonary arterial pressure (systolic, r=0.87; diastolic, r=0.75; mean, r=0.85; each p<0.001) was found in all the patients examined. There were significant positive correlations between plasma ANF concentration and systolic right ventricular pressure (r=0.86, p<0.001), pulmonary capillary wedge pressure (r=0.50, p<0.01) and mean right atrial pressure (r=0.39, p<0.05). A weak but significant negative correlation was found between plasma ANF concentration and stroke volume index (r=-0.43, p<0.05). The correlation coefficient between plasma ANF concentration and mean pulmonary arterial pressure was significantly stronger than those between plasma ANF concentration and pulmonary capillary wedge pressure, and between plasma ANF concentration and mean right atrial pressure (p<0.05 and p<0.01, respectively).In 10 patients with mitral valvular disease, significant correlations with plasma ANF concentration were also found for pulmonary arterial pressure (systolic, r=0.80; diastolic, r=0.82; mean, r=0.82; each p<0.01).These findings suggest that pulmonary arterial pressure may play an important role in the mechanism of release of ANF from atrial cardiocytes.
- International Heart Journal刊行会の論文
著者
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Hiwada Kunio
Second Department Of Internal Medicine Ehime University School Of Medicine
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Kokubu Tatsuo
Second Department Of Internal Medicine Ehime University
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MATSUO Hisayuki
Second Department of Biochemistry, Miyazaki Medical College
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NAGAE Akihiro
Second Department of Internal Medicine, Ehime University School of Medicine
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KAZATANI Yukio
Second Department of Internal Medicine, Ehime University School of Medicine
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JOH Tadafumi
Department of Cardiology, Ehime Prefectural Central Hospital
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