Electrophysiological effects of diphenylhydantoin in patients with sinus node dysfunction.

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概要

• 論文の詳細を見る

• The electrophysiological effects of intravenous administration of diphenylhydantoin (DPH) (5mg/Kg, maximum 250mg) were studied in 20 patients with sinus node dysfunction (SND). DPH shortened spontaneous cycle length (SCL) in 3 patients and lengthened it in 3. Maximum corrected sinus node recovery time (max CSRT) was prolonged in 7 patients and shortened in 3. Estimated sinoatrial conduction time was prolonged in 3 patients and shortened in 2 of 10 patients in whom this measurement was possible. However, these changes were not statistically significant. Neither were there any significant changes in PA, AH and HV intervals nor refractory periods of the atrium, the AV node and the ventricle. DPH prolonged SCL and/or max CSRT in 9 of 20 patients with SND, and it was suggested that DPH has depressant effects on the sinus node in some patients with SND. Thus, this drug should be used with caution in the treatment of ventricular arrhythmias accompanied by sinus node dysfunction.

• International Heart Journal刊行会の論文

著者

• Sueda Takashi

  First Department Of Surgery Hirosima Univesity

• Tateishi Hironobu

  Internal Medicine of Hiroshima City Hospital.

• Kajiyama Goro

  First Department Of Internal Medicine

• Tsuchioka Yukiko

  First Department Of Internal Medicine Hiroshima University

• Matsuura Hideo

  First Deparment Of Internal Medicine Hiroshima University Faculty Of Medicine

• HASHIMOTO Masaki

  First Department of Internal Medicine, Hiroshima University School of Medicine

• KUROGANE Hiroyuki

  First Department of Internal Medicine, Hiroshima University School of Medicine

• MITSUDA Hiroki

  Internal Medicine, Asa City Hospital

• SATO Hikaru

  Internal Medicine Hiroshima City Hospital

• TSUCHIOKA Yukiko

  First Department of Internal Medicine, Hiroshima University School of Medicine

• YAMAOKA Kaoru

  First Department of Internal Medicine, Hiroshima University School of Medicine

• YAMAMOTO Masaharu

  First Department of Internal Medicine, Hiroshima University School of Medicine

• TATEISHI Hironobu

  Internal Medicine Hiroshima City Hospital

• TATEISHI Hironobu

  Internal Medicine, Hiroshima City Hospital

• SUEDA Takashi

  First Department of Internal Medicine, Hiroshima University School of Medicine

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