Intralymphocytic Sodium and Free Calcium Concentration in Relation to Salt Sensitivity in Patients with Essential Hypertension

概要

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In order to clarify the relation between salt sensitivity and changes in intracellular sodium ([Na]i) and free calcium concentration ([Ca^<2+>]i) after salt loading, [Na]i and [Ca^<2+>]i were determined in lymphocytes of twenty patients with essential hypertension under a low salt diet (3 g/day) and a high salt diet (20 g/day) for seven days, respectively. They were classified as "salt-sensitive" (n=10) or "nonsalt-sensitive" (n=10) on the basis of the changes in blood pressure after salt loading. Both lymphocytic [Na]i and [Ca^<2+>]i were significantly increased with salt loading in salt-sensitive patients (p<0.05 for both), while they were not affected by salt loading in nonsalt-sensitive patients. Lymphocytic [Ca^<2+>]i showed a positive correlation with lymphocytic [Na]i under both low salt diet (r=0.62, p<0.01) and high salt diet (r=0.70, p<0.01) in all patients in both groups. In addition, a close and positive correlation was observed between the changes in lymphocytic [Na]i and those in lymphocytic [Ca^<2+>]i after salt loading in all patients in both groups (r=0.80, p<0.001). These results suggest that the increase in [Ca^<2+>]i, possibly linked with the increase in [Na]i, may be involved in elevation of blood pressure in the salt-sensitive patients after salt loading.
社団法人日本循環器学会の論文
1987-10-20