Electrophysiological effects of propranolol in patients with sinus node dysfunction.
スポンサーリンク
概要
- 論文の詳細を見る
The electrophysiological effects of intravenous propranolol (0.15mg/kg) were studied in 26 patients with sinus node dysfunction (SND group) and 9 patients with normal sinus node function (control group). Spontaneous cycle length and AH interval were significantly increased in the control and SND groups after propranolol. PA and HV intervals, calculated sinoatrial conduction time and refractory periods of the atrium, AV node and ventricle were not significantly changed in either group. Maximum corrected sinus node recovery time (max CSRT) was not changed in the control group, but it was significantly prolonged in the SND group. These results of the overdrive suppression test were in disagreement with those of previous studies. Propranolol lengthened spontaneous cycle length (by more than 200 msec) and/or max CSRT (by more than 1000 msec) in 8 of 26 patients with SND. Thus, it is suggested that propranolol should be used with caution in patients with SND.
- International Heart Journal刊行会の論文
著者
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MATSUURA Hideo
First Department of Internal Medicine, Hiroshima University School of Medicine
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Yuasa Akira
First Department Of Internal Medicine Hiroshima University School Of Medicine
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Matsumoto Koji
First Department Of Internal Medicine Hiroshima University School Of Medicine
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Tateishi Hironobu
Internal Medicine of Hiroshima City Hospital.
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Sato Hikaru
Internal Medicine of Hiroshima City Hospital.
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Kajiyama Goro
First Department Of Internal Medicine
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Tsuchioka Yukiko
First Department Of Internal Medicine Hiroshima University
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Matsuura Hideo
First Deparment Of Internal Medicine Hiroshima University Faculty Of Medicine
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FUJII Hideaki
First Department of Internal Medicine, Hiroshima University School of Medicine
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MASAOKA Satoko
First Department of Internal Medicine, Hiroshima University School of Medicine
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SATO Hikaru
Internal Medicine Hiroshima City Hospital
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TATEISHI Hironobu
Internal Medicine Hiroshima City Hospital
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