Plasma Adrenaline and Noradrenaline Concentrations of the Spontaneously Hypertensive Rat

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概要

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• The role of the sympathetic nervous system in the mechanism of blood pressure rise in spontaneously hypertensive rats (SHR) was investigated by measuring plasma levels of adrenaline and noradrenaline in 5-week-old, 7-week-old, 6-month-old, and 12-month-old SHR. Age-matched normotensive Wistar-Kyoto rats (WKY) were used as control animals. Blood samples were collected through an indwelling catheter in a conscious state. In 5-week-old and 7-week-old SHR both plasma adrenaline and noradrenaline concentrations were significantly higher than those of WKY. In 6-month-old SHR plasma noradrenaline was significantly higher than that of WKY, while plasma adrenaline was not significantly different. In 12-month-old SHR the plasma levels of both adrenaline and noradrenaline were not different from those of WKY. This study indicated more distinct increase in plasma noradrenaline than in plasma adrenaline in young SHR, and also suggests that peripheral sympathetic activity and the adrenal medulla may play important roles in the development of hypertension in SHR

• International Heart Journal刊行会の論文

著者

• Pak Chun

  Third Division Department Of Internal Medicine Faculty Of Medicine

• PAK Chun

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• PAK Chun

  Third Department of Internal Medicine, Faculty of Medicine, Kyoto University

関連論文

• PREVENTION OF NEPHROSCLEROSIS AND CARDIAC HYPERTROPHY BY CAPTOPRIL TREATMENT OF SPONTANEOUSLY HYPERTENSIVE RATS
• Cryoactivation of Inactive Renin in Human Plasma : VIII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• Effects of Beta-Adrenergic Blocking Agents on the Blood Pressure, Plasma Renin Activity and Hemodynamics of Hypertensive Patients
• Plasma Adrenaline and Noradrenaline Concentrations of the Spontaneously Hypertensive Rat
• Effect of Propranolol on Blood Pressure and Plasma Renin Concentration in Renovascular Hypertensive Rats
• Molecular Weight of Renal Renin
• Plasma Catecholamine of Spontaneously Hypertensive Rats
• Effect of diltiazem, captopril, α-metyldopa in the Stroke Prone Spontaneously Hypertensive Rat

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