Anti-Heart Antibodies in Chronic Cor Pulmonale
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概要
- 論文の詳細を見る
In patient with chronic cor pulmonale which was caused by pul-monary emphysema, circulating autoantibodies against the heart tissue were investigated by hemagglutination and hemagglutination-inhibition techniques using normal rabbits myocardium as antigen. Quantitative analysis of serum IgG, IgA and IgM were carried out by use of the radial immunodiffusion method. These results were compared with clinical findings, specifically cardiopulmonary hemodynamics and patho-physiological changes.Circulating anti-heart antibodies were found in 13 out of 25 (52 per cent) patients with a definite complication of chronic cor pulmonale. The titers of circulating anti-heart antibodies indicated a good correla-tion with hypoxia and pulmonary hypertension and/or pulmonary circu-latory disturbance. Furthermore, a good correlation was noted between anti-heart antibody titers and the serum IgG levels.These data could be utilized in evaluation and discussion of the pathophysiological findings of the patients with chronic cor pulmonale.
- International Heart Journal刊行会の論文
著者
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Mise Junichi
Department Of Community And Family Medicine Jichi Medical School
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Yamamoto Toru
Department Of Anesthesiology Nihon University School Of Medicine
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KUBO Fumitaka
Department of Internal Medicine, Yamaguchi University School of Medicine
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