Effects of Kö 1366 on the Hemodynamics of the Normotensive and Hypertensive Elderly Subjects
スポンサーリンク
概要
- 論文の詳細を見る
The hemodynamic effects of a new adrenergic β-receptor blocking agent, Kö 1366 were investigated in normotensive and hypertensive elderly subjects. This study, in its important part, was carried out to clarify whether the intrinsic sympathomimetic activity of Kö 1366 modified the hemodynamic changes due to β-adrenergic blocking action or not. Hemodynamic changes elicited by intravenously administered Kö 1366 (0.05mg/Kg) were correlated with age, cardiac index, and electro-cardiographic findings, respectively. With reference to age in normoteinsve subjects, Kö 1366 caused no significant differences in rate of changes of various hemodynamic items between 3 age groups. Normotensive elderly subjects were divided into 3 groups according to cardic index. Cardiac index decreased greatly in high cardiac index group, slightly in normal cardiac index group, whereas it increased greatly in low cardiac index group. Stroke volume index showed the same tendency as cardiac index. Hypertensive elderly subjects were, also divided into 2 groups according to cardiac index. Again, cardiac index decreased in higher cardiac index group, while it increased in lower cardiac index group, though a statistical evaluation showed only a tendency of significant difference be-tween 2 groups. In the next, hypertensive elderly subjects were divided into 2 groups according to electrocardiographic findings of left ventricular hypertrophy. Cardiac index decreased in the subjects without electro-cardiographic changes, while it increased in the subjects with electro-cardiographic changes. Stroke volume index of both groups increased: a greater increase in the subjects with electrocardiographic changes and a tendency of significant difference between 2 groups was recognized.These results suggested that Kö 1366 exhibited the intrinsic symathomimetic activity on the inotropism in the hearts with depressed contractile function of both normotensive and hypertensive subjects, thereby canceling the negative chronotropic action of this agent. This could be a more advantageous point of Kö 1366 in the treatment of elderly subjects with cardiac diseases than other agents without the intrinsic sympathomimetic activity.
- International Heart Journal刊行会の論文
著者
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Terasawa Fujio
Yokufukai Geriatric Hospital
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Ikeda Masao
Third Dept. Intern. Med., Fac. Med., Univ. of Tokyo.
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LIE HON
Third Dept. of Intern. Med., Faculty of Med., Univ. of Tokyo
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Terasawa Fujio
Univ. Of Tokyo
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TERASAWA Fujio
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Seki Masuji
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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SUZUKI Takaomi
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo and the Yokufukai Ge
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Ikeda Masao
Third Dept. Intern. Med. Fac. Med. Univ. Of Tokyo.
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Terasawa Fujio
3rd Dept. Of Internal Med. Tokyo University School Of Medicine.
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LIE Hon
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo and the Yokufukai Geriatric Hospital
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IKEDA Masao
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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SUZUKI Takaomi
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo and the Yokufukai Geriatric Hospital
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TERASAWA Fujio
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo and the Yokufukai Geriatric Hospital
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SEKI Masuji
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo and the Yokufukai Geriatric Hospital
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