Renal Factor Responsible for Acute Vascular Lesions in Experimental Renovascular Hypertension
スポンサーリンク
概要
- 論文の詳細を見る
The nature of vascular toxic substance (necrotizing substance) in the extracts of clamped rabbit renal cortex was investigated. Analysis of the kidney tissue extracts by means of column chromatography, measurement of ultraviolet absorption, dialysis and heating test revealed that the substance was not renin, but rather a substance with lower molecular weight which was nondialyzable, heat-stable (not destroyed by heating for 10 min. at 100°C). Parenteral administration of this substance, without elevating blood pressure, caused fibrinoid lesions of the small cerebral arteries and arterioles probably due to the increased permeability of the vessel walls, as indicated by the histological changes of the damaged vessels.
- International Heart Journal刊行会の論文
著者
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NAKAO KIKU
Third Dept. of Intern. Med., Faculty of Med., Univ. of Tokyo
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Yamaguchi Hiroshi
Third Department Of Internal Medicine Yamagata University School Of Medicine
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Ikeda Masao
Third Dept. Intern. Med. Fac. Med. Univ. Of Tokyo.
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Kurihara Hiroshi
Third Dept. Intern. Med. Fac. Med. Univ. Of Tokyo.
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YAMAGUCHI Hiroshi
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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FUJII Jun
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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KURIHARA Hiroshi
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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IKEDA Masao
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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NAKAO Kiku
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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