新鎮痛薬1-(m-methoxyphenyl)-2-dimethylamino methyl cyclohexanol(1)hydrochloride(K-315)の薬理学的研究-3-K-315の鎮痛効果と脳内CA,5-HTの関係について

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K-315 in an effective analgesic dose did not vary monoamine levels (nor-adrenaline, dopamine and 5-hydroxytryptamine) in mouse brain. The analgesic action of K-315 was potentiated by cocaine, but not modified by tetrabenazine and p-chlorophenylalanine, though lowered by reserpine and α-methyltyrosine. K-315 was not included in the same category as the other 4 analgesics (morphine, pethidine, dihydrocodeine and aminopyrine), regarding modification of analgesic effects due to variation of monoamine contents in the brain.
社団法人日本薬理学会の論文