脳波ならびに痛覚求心路におよぼす影響 (新鎮痛薬1-(m-methoxyphenyl)-2-dimethylaminomethyl cyclohexanol(1)hydrochloride(K-315)の薬理学的研究-1,2-)

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Effects of a new analgesic drug, K-315, on the central nervous system were investigated electro-encephalographically and neurophpsiologically. Results are as follows: 1. K-315 slightly synchronized spontaneous EEG, and inhibitory actions of arousal responses following stimulation of subcortical areas were less than those of pethidine. 2. K-315 slightly potentiated recruiting and augmenting responses in rabbits, but did not affect the induced spindle burst. 3. K-315 strongly inhibited cortical responses evoked by splanchnic nerves stimulation in the equivalent dose of morphine in cats. 4. K-315 showed differential actions from that of morphine in cortical responses evoked by CM stimulation.
社団法人日本薬理学会の論文