ホルモン投与による乳腺の誘起発達に関する生化学的研究

概要

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Experiments were performed to determine the optimal amount of estrogen (ES) and progesterone (PR) required for the development of the mammary gland and elucidate the quantitative interaction of both hormones on the gland. The results obtained are as follows:1) The nearly maximum development of the mammary gland was obtained with such combination as 5μg ES and 3mg PR, 30μg E5 and 2-3μg PR, and 100μg E5 and 1mg PR, 2) Growth of the mammary gland does not necessarily require prolonged treatment with ES and PR. A combined dose of 30μg ES and 2mg PR produced the development of the mammary gland in seven days to the same extent as that in fourteen days.3) The area covered by the mammary gland does not seem to have been affected with the ES and PR treatment.4) Growth of the ducts was stimulated by treatment with ES, but a large dose (100μg) of this hormone resulted rather in the inhibition of growth. No evidence could be given for the stimulation of growth of the ducts with PR alone. It wassuggested, however, that PR promoted the action of ES on the ducts.5) The alveolar growth was moderately increased in amount by treatment with ES alone. The combination of ES and PR exerted a significant action on the alveolar growth. The quantitative interaction of ES and PR on the alveolar growth was discussed.
社団法人日本畜産学会の論文