酵素反応にあらわれる遅い遷移相

概要

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The present review deals with slow trangent phenomena in the enzyme reaction accompanied by time lag or burst phase in a range of time scale from several minutes to one second in the initial time course: the observation of these phases may not require any special techniques for rapid reaction measurement.<BR>The phenomenon is often observed in oligomeric regulatory enzymes rather than in monomeric enzymes.<BR>The phenomenon may involve a slow conversion of one form of the enzyme to a different form (s) with different activity. The reaction mechanism illustrating such phenomenon is discuseed in connection with cooperativity (sigmoidal relation between steady-state rate and ligand concentration). In addition, monomeric enzyme reactions with slow trangent phases and enzyme reactions with the trangents causing in ligand side but not in the enzyme are also reviewed.
日本生物物理学会の論文