Antimicrobial Activity of Gel-Entrapped Catechins toward Oral Microorganisms
スポンサーリンク
概要
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The oral cavity contains almost half of the commensal bacterial population present in the human body. An increase in the number of these microorganisms may result in systemic diseases such as infective endocarditis and aspiration pneumonia as well as oral infections. It is essential to control the total numbers of these microorganisms in order to suppress disease onset. Thus, we examined the antimicrobial activity of a newly developed gel-entrapped catechin (GEC) preparation against oral microorganisms. The minimum inhibitory concentration (MIC) of GEC was determined based on the relationship between a modified agar diffusion method and a broth microdilution method. GEC inhibited the growth of the Actinomyces, periodontopathic bacteria and Candida strains tested, but did not inhibit the growth of the oral streptococci that are important in the normal oral flora. Commercially available moisture gels containing antimicrobial components showed antimicrobial activity against all of the tested strains. After a series of washes and after a 24-h incubation, GEC retained the antimicrobial activity of the catechins. Catalase prevented GEC-induced growth inhibition of Actinomyces naeslundii and Streptococcus mutans suggesting that hydrogen peroxide may be involved in the antimicrobial activity of catechins. These results suggest that GEC may be useful for controlling oral microorganism populations and reducing the accumulation of dental plaque, thereby helping to prevent periodontal disease and oral candidiasis.
著者
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Saito Hideo
Department Of Chemistry Graduate School Of Pure And Applied Sciences University Of Tsukuba
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Ochiai Kuniyasu
Department Of Microbiology Nihon University School Of Dentistry
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Tamura Muneaki
Department Of Microbiology Nihon University School Of Dentistry
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Kikuchi Kuniyoshi
Department of Microbiology, Nihon University School of Dentistry
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Ishigami Tomohiko
Department of Partial Denture Prosthodontics, Nihon University School of Dentistry
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Toyama Yoshio
Medical Nutrition Section, Nutrition Foods Department, Division of Research and Development, Researc
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Takami Masao
Nuritional Evaluation, Product Development Section, Nutritional Marketing Department II, Nutritional
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Toyama Yoshio
Medical Nutrition Section, Nutrition Foods Department, Division of Research and Development, Research and Development Center, Meiji Dairies Corporation
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Takami Masao
Nuritional Evaluation, Product Development Section, Nutritional Marketing Department II, Nutritional Consolidated Marketing Division, Meiji Dairies Corporation
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