Purulent Meningitis Caused by Actinomyces Successfully Treated with Rifampicin: A Case Report
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概要
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A 64-year-old woman presented with fever and headache. Lumbar puncture revealed cerebrospinal fluid (CSF) that contained 67,386 /mm3 of WBC; CSF culture revealed Actinomyces species. She was diagnosed with purulent meningitis caused by actinomyces, and treated with intravenous ampicillin 12 g/day. The administration of ampicillin was effective, but not sufficient to control the inflammation in CSF. CSF inflammation persisted and a gradual increase in granulation tissue was found in the subdural space on lumbar MRI. After administration of rifampicin 450 mg/day, the CSF was normalized and the enhancement of granulation tissue decreased. The patient completely recovered 5 months after the therapy was initiated. We suggest that rifampicin may be an option for the treatment of meningitis caused by actinomyces.
著者
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Kamitani Hideki
Department Of Neurosurgery Faculty Of Medicine Tottori University
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Asai Yasumasa
Department Of Physiology Tottori University
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Nakayasu Hiroyuki
Department Of Neurology Tottori Prefectural Central Hospital
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NAKASHIMA Kenji
Division of Microbiology, Department of Pathological Sciences, Faculty of Medical Sciences
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Imamura Keiko
Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University
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Kamitani Hideki
Department of Neurosurgery, Tottori Prefectural Kousei Hospital, Japan
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