Pathological Role of D-amino Acid-Containing Proteins and Advanced Glycation End Products in the Development of Age-Related Macular Degeneration
スポンサーリンク
概要
- 論文の詳細を見る
Age-related macular degeneration has become a leading cause of blindness in most developed countries worldwide. In the early phase of the disease, abnormal, yellow-colored material called “drusen” appears between the retinal pigment epithelial cells and Bruchs membrane. Immunohistochemical studies have confirmed that drusen contain D-amino acid-containing proteins and advanced glycation end products. In addition, retinal pigment epithelial cells express a receptor for AGEs (RAGE). These findings indicate that persistent interaction between AGEs and RAGE is involved in the development of age-related macular degeneration.
著者
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FUJII Noriko
Research Reactor Institute, Kyoto University
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Takazawa Yutaka
Department Of Cardiothoracic Surgery And Human Pathology The University Of Tokyo Graduate School Of
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Oshika Tetsuro
Department Of Ophthalmology Institute Of Clinical Medicine University Of Tsukuba
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Kaji Yuichi
Department Of Ophthalmology Faculty Of Medicine University Of Tokyo
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Fujii Noriko
Research Reactor Inst. Kyoto Univ.
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Fukayama Masashi
Department Of Diagnostic Pathology Kanto Teishin Hospital
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Oshika Tetsuro
Department of Ophthalmology, University of Tsukuba Institute of Clinical Medicine
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Fukayama Masashi
Department of Human Pathology, University of Tokyo Graduate School of Medicine
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Kaji Yuichi
Department of Ophthalmology, University of Tsukuba Institute of Clinical Medicine
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Takazawa Yutaka
Department of Human Pathology, University of Tokyo Graduate School of Medicine
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