Fabrication of biodegradable β-tricalcium phosphate/poly(L-lactic acid) hybrids and their in vitro biocompatibility

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概要

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• Hybrids of β-tricalcium phosphate (β-TCP) and poly(L-lactic acid) (PLLA) have been fabricated, which can be expected to be a novel filler for biodegradable bone grafting. Firstly, porous β-TCP ceramics have been made of calcium-phosphate fiber synthesized by homogeneous precipitation method. Then, the hybrids have been fabricated by introducing PLLA having high-molecular-weight into the open pores of the porous β-TCP ceramics. The mechanical property was enhanced, for example, by annealing the hybrids at 140°C for 24 h; the bending strength was 17.1 MPa, which was about 1.5 times that of the porous β-TCP ceramics. The biocompatibility has been examined using osteoblastic cell, MC3T3-E1, and found to be comparable to that of pure β-TCP ceramics.

著者

• AIZAWA Mamoru

  Department of Applied Chemistry, School of Science and Technology, Meiji University

• RIKUKAWA Masahiro

  Department of Chemistry, Sophia University

• SUGIYAMA Nami

  Department of Chemistry, Sophia University

• ORIBE Kazuya

  SHOWA IKA KOHGYO Co., Ltd.

• Oribe Kazuya

  Showa Ika Kohgyo Co. Ltd

• SHIGEMITSU Yusuke

  Department of Applied Chemistry, Graduate School of Science and Technology, Meiji University

• Aizawa Mamoru

  Department Of Applied Chemistry Meiji University

• Rikukawa Masahiro

  Department Of Chemistry Sophia University

• AIZAWA Mamoru

  Department of Applied Chemistry, Graduate School of Science and Technology, Meiji University

• ORIBE Kazuya

  SHOWA IKA KOHGYO, Co., Ltd.

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