Syntheses of Single-Crystal Apatite Particles with Preferred Orientation to the a- and c-Axes as Models of Hard Tissue and Their Applications
スポンサーリンク
概要
- 論文の詳細を見る
Hydroxyapatite [Ca10(PO4)6(OH)2; HAp] is the mineral component of vertebrate hard tissues and an important raw material for biomaterials. The HAp crystal belongs to a hexagonal system and has two types of crystal plane with different atomic arrangements: positively charged calcium ions are mainly present in the a(b)-planes, while negatively charged phosphate ions and hydroxyl groups are mainly present in the c-planes. In vertebrate long bone surfaces, HAp crystals have a c-axis orientation, which leads to the development of the a(b)-plane; while in tooth enamel surfaces, they have an a(b)-axis orientation, which leads to the development of the c-plane. However, it is not clear why the orientations of long bone and tooth enamel are in different crystal planes. In order to clarify this question, we have synthesized single-crystal apatite particles with preferred orientation to the a- and c-axes as models for bone and teeth enamel. This review first describes the syntheses process of single-crystal apatite particles with preferred orientation to a(b)- and c-axes and then discusses specific protein adsorption to the crystal surface of the resulting plate- and fiber-shaped apatite particles with different surface charges. In addition, porous apatite-fiber scaffolds (AFSs) fabricated using the fiber-shaped apatite particles and their application to tissue engineering of bone are described on the basis of the three-dimensional cell culture of mesenchymal stem cells derived from rat bone marrow using the AFS settled into a radial-flow bioreactor.
- 公益社団法人 日本薬学会の論文
著者
-
Aizawa Mamoru
Department Of Applied Chemistry Meiji University
-
Matsuura Tomokazu
Division of Central Clinical Laboratory, Jikei University Hospital
-
Zhuang Zhi
Department of Applied Chemistry, Meiji University School of Science and Technology
関連論文
- Novel chemoembolization using calcium-phosphate ceramic microsphere incorporating TNP-470, an anti-angiogenic agent
- Fabrication of novel bioresorbable β-tricalcium phosphate cement on the basis of chelate-setting mechanism of inositol phosphate and its evaluation
- Ring-opening Bulk Polymerization of L-Lactide in Porous Hydroxyapatite
- 気管支喘息児における血清ビタミンA濃度の検討
- 1P-321 圧力制御下での球殻状蛋白質を鋳型として用いたCaナノ粒子作製(バイオエンジニアリング,第46回日本生物物理学会年会)
- 2P559 In Vitro Synthesis of Calcium Nanoparticles Using the Protein Cage of Apoferritin(53. Bioengineering,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- Fabrication of biodegradable β-tricalcium phosphate/poly(L-lactic acid) hybrids and their in vitro biocompatibility
- Preparation of magnesium silicon nitride powder by the carbothermal reduction technique
- Detection of Kinase Activity Using a Synthetic System of Gold Nanoparticles in HEPES Buffer
- 3C1546 Inositol hexaphosphate and its apatite cements -induced ROS generation and their biological effects on human cells(3C Molecular genetics & Gene expression, Development & Differentation, Radiobiology & Active oxygen,The 49th Annual Meeting of the Bi
- Syntheses of Single-Crystal Apatite Particles with Preferred Orientation to the a- and c-Axes as Models of Hard Tissue and Their Applications
- Noncovalent functionalization of boron nitride nanotubes using water-soluble synthetic polymers and the subsequent preparation of superhydrophobic surfaces
- DNA-templated Fabrication of Biphasic Calcium Phosphate Ceramics with a Bimodal Pore Structure for Tissue Engineering