Fabrication of chelate-setting hydroxyapatite cements from four kinds of commercially-available powder with various shape and crystallinity and their mechanical property(<Feature> Ceramics for Biomedical Applications in Asian Countries)

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概要

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• Hydroxyapatite (Ca_<10>(PO_4)_6(OH)_2; HAp) is one of inorganic components of bone and teeth, and has an osteoconductivity and execellent biocompatibility. Thus, the HAp has been used as biomaterials for bone graftings. Clinically-used HAp cements are set on the basis of the acid-base reaction of Ca_4O(PO_4)_2 and CaHPO_4. This mechanism accompany the changes of pH during hardening, leading to inflammation around tissues, together with slow setting time. We have succeeded to develop novel HAp cement, which is created by mixing the HAp powder modified with inositol phosphate (IP6) and water. The present IP6-HAp cement is set based on the chelate-bonding of IP6 without the acid-base reaction. The IP6 is not only biocompatible but also has able to chelate to some metal ions as strongly as EDTA. In the present study, we fabricated four kinds of IP6-HAp cements using commercially-available HAp powders with diferent morphology and specific surface area (SSA): HAp-100 (fine particle), HAp-200 (hexagonal shape), HAp-400 (plate shape), and s-HAp (spherical shape). Among the cement specimens examined, the IP6/HAp-100 cement derived from HAp-100 powder had maximum compressive strength of 10MPa under following condition: Powder/Liquid (P/L) ratio=1/0.45[w/w]. The HAp-100 powder was composed of microcrystals with the highest SSA of 62.4m^2・g^<-1> among the HAp powder used in the present work. On the other hand, the compressive strength of the IP6/HAp-200 cements showed the lowest value of 2MPa under following condition: P/L ratio=1/0.35[w/w]. The HAp-200 powder of a starting material was composed of hexagonal-shaped crystals, and had the lowest SSA of 7.0m^2・g^<-1>. These results indicate that the compressive strength of novel IP6/HAp cements was affected by powder properties, especially, the morphology and SSA of starting HAp powders.

• 社団法人日本セラミックス協会の論文
• 2008-01-01

著者

• Oribe Kazuya

  Showa Ika Kohgyo Co. Ltd

• Aizawa Mamoru

  School Of Science And Technology Meiji University

• Yoshikawa Akifumi

  School Of Science And Technology Meiji University

• HORIGUCHI Yukiko

  School of Science and Technology, Meiji University

• Horiguchi Yukiko

  School Of Science And Technology Meiji University:showa Ika Kohgyo Co. Ltd

関連論文

• Fabrication of novel bioresorbable β-tricalcium phosphate cement on the basis of chelate-setting mechanism of inositol phosphate and its evaluation
• 1P282 イノシトール6リン酸(IP6)とヒドロキシアパタイトIP6の活性酸素阻害作用と生物学的効果(放射線生物/活性酸素,第48回日本生物物理学会年会)
• Fabrication of biodegradable β-tricalcium phosphate/poly(L-lactic acid) hybrids and their in vitro biocompatibility
• Fabrication of chelate-setting hydroxyapatite cements from four kinds of commercially-available powder with various shape and crystallinity and their mechanical property( Ceramics for Biomedical Applications in Asian Countries)

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