Influence of Low-Grade Inflammation on Plasma B-type Natriuretic Peptide Levels
スポンサーリンク
概要
- 論文の詳細を見る
Objective B-type natriuretic peptide (BNP) is a cardiac hormone. The results of previous in vitro studies suggest that neurohumoral factors, and not only hemodynamic factors, may cause BNP secretion. In this study, we examined the impact of serum C-reactive protein (CRP) levels on the relationship between echocardiographic parameters and plasma BNP levels in patients with cardiovascular diseases. Methods and Patients The study population comprised 417 patients who visited our cardiovascular unit with a problem. Both blood sampling and echocardiography were performed within one month. Results Multiple regression analysis showed that plasma BNP levels were negatively correlated with male gender, body mass index, and estimated glomerular filtration rate, and positively correlated with serum CRP levels and left ventricular end-systolic dimension (LVDs). The study population was divided into two groups based on the 75th percentile of the serum CRP levels. Single regression analysis showed that a regression line between LVDs and plasma BNP levels was steeper in the group of patients with CRP levels above the 75th percentile. Multiple regression analysis revealed that the interaction term (LVDs × CRP) was significant, which means LVDs had more impact on plasma BNP levels at higher CRP levels. Conclusion Plasma BNP levels increased with respect to the severity of cardiac dysfunction and serum CRP levels, and should therefore be considered a collective or total marker for life-threatening conditions including systemic inflammation, and not simply as a marker of cardiac dysfunction in patients with cardiovascular diseases.
著者
-
HONGO Kenichi
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine
-
Komukai Kimiaki
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
-
Kawai Makoto
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
-
Yoshimura Michihiro
Division Of Cardiology Department Of Internal Medicine Jikei University School Of Medicine
-
Ogawa Takayuki
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
-
Inoue Terumasa
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
-
Minai Kosuke
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
-
Nojiri Ayumi
Division Of Cardiology Department Of Internal Medicine Jikei University School Of Medicine
-
Nakane Tokiko
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
-
Matsushima Masato
Division Of Clinical Epidemiology Research Center For Medical Science Jikei University School Of Medicine
-
Ogawa Takayuki
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine
関連論文
- High Incidence of Repeat Anginal Attacks Despite Treatment With Calcium-Channel Blockers in Patients With Coronary Spastic Angina(Ischemic Heart Disease)
- PJ-781 A "Point of no return" in Atrial Fibrillation-induced Cardiomyopathy(Arrhythmia, diagnosis / Pathophysiology / EPS(16)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 第10回医科学フォーラム
- Unsuccessful Reperfusion Due to No-reflow Phenomenon in Acute Inferior Myocardial Infarction : A Case Report with Postmortem Examination (Case Report)
- OJ-134 Aldosterone, but Not Angiotensin II, Reduces Angiotensin Converting Enzyme 2 Gene Expression Levels in Cultured Neonatal Rat Cardiomyocytes(OJ23,Hypertension, Basic (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- Aldosterone, but Not Angiotensin II, Reduces Angiotensin Converting Enzyme 2 Gene Expression Levels in Cultured Neonatal Rat Cardiomyocytes
- PJ-321 Clinical Factors Affecting Serum Potassium Concentration(Heart failure, clinical(16)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 2 Spastic Angina Genetic (SAGE) Study(Plenary Session 7 (PL-7) (M) Genomic Approaches to Cardiovascular Diseases : Present and Future,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats
- Infiltration of Macrophages Through the Atrial Endocardium of Inflammation-Induced Rats : Contribution of Fractalkine
- PJ-751 Impact of Smoking on Restenosis after Percutaneous Coronary Intervention (PCI) with Bare Metal Stents (BMS)(PJ126,Smoking/Alcohol/Life Style (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-750 Current Smoking is the Most Important Risk Factor with First Diagnosed Acute Coronary Syndrome(PJ126,Smoking/Alcohol/Life Style (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-507 Association of QTc Prolongation with Low Blood pH in Diabetic Patients with Acute Heart Failure Status(PJ085,Heart Failure (Pathophysiology) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-479 Additional Evaluation for Ischemia is Required to Perform CAG after MSCT(PJ081,CT/MRI (Coronary/Vascular) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-435 Promotion of Macrophage Infiltration and Interstitial Fibrosis in Diabetic Rat Atria(PJ073,Arrhythmia, Others (Basic) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-167 Factors for Long Term Hospitalization with Chronic Heart Failure(PJ028,Cardiovascular Pharmacology (Basic), Cost-health care system/DPC/Laws (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-081 Relationship between Delayed Enhancement of Cardiac MRI and Clinical Features in Hypertrophic Cardiomyopathy(PJ014,Cardiomyopathy/Hypertrophy (Clinical) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- PE-332 One-Year Angiographic Outcome after Balloon Dilation of In-Stent Restenosis Inside Sirolimus-Eluting Stent(PE056,Coronary Revascularization, PCI (Restenosis/Others) 3 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese
- PE-256 Regional Differences in Removal of Atrial Natriuretic Polypeptide in the Human Lungs(PE043,Heart Failure (Biomarker) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- P-5.平滑筋X線回折による筋フィラメント格子状配列動態解析の試み(ポスター発表,一般演題,第51回日本平滑筋学会総会)
- Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008) : Digest Version
- Simultaneous Elevation of the Levels of Circulating Monocyte Chemoattractant Protein-1 and Tissue Factor in Acute Coronary Syndromes
- IS040 Positive association between essential hypertension and Glu298Asp polymorphism in the endothelial nitric oxide synthase gene
- PE-008 Infiltration of Macrophages through Atrial Endocardium by Upregulation of Fractalkine Expression in Inflammation-induced Rats.(Arrhythmia, basic(03)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-007 Accumulation of Advanced Glycation End Products in Human Fibrillated Atria(Arrhythmia, basic(03)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-148 Involvement of SPARC Protein Expression in Interstitial Fibrosis in Human Fibrillated Atria(Arrhythmia, basic(01)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- O-33. ミオシンII阻害薬ブレビスタチンがスキンド気管平滑筋収縮に与える影響(8.ミオシン関連,一般演題,第50回日本平滑筋学会総会)
- P-23. フェノキサジン化合物2-Amino-4, 4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-oneによるモルモット盲腸紐収縮抑制のメカニズム(第49回日本平滑筋学会総会)
- 過酸化水素がモルモット大動脈平滑筋スキンド標本収縮に与える影響(一般演題「血管」)
- Presenilin 2 Regurates Excitation-contraction Coupling in Hearts(Excitation-contraction Coupling/Ion Channel 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Beta-Adrenergic Stimulation Failed to Regulate Intracellular Ca^ Concentration and Isometric Tension in SERCA2a Overexpressing Heart
- Decreased Renal Function as an Independent Predictor of Re-Hospitalization for Congestive Heart Failure
- PJ-851 Abnormal Heart Rate Variability Predicts Future Cardiovascular Events in Patients with Structurally Normal Heart(ECG / Body surface potential mapping / Holter(07)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circul
- Effects of Spironolactone During an Angiotensin II Receptor Blocker Treatment on the Left Ventricular Mass Reduction in Hypertensive Patients With Concentric Left Ventricular Hypertrophy
- DPE-069 Angiotensin II Type 1 Receptor Blockade Rescued the Mouse Model of Dilated Cardiomyopathy from Sudden Cardiac Death(DPE12,Cardiomyopathy/Hypertrophy (Basic) (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- Inhibition of the Renin-Angiotensin System Prevents Re-Hospitalization of Heart Failure Patients With Preserved Ejection Fraction
- PE-038 Decreased Ca^ Sensitivity of the Myofilament is Critical for the Development of Cardiac Dysfunction in Mouse Model of Dilated Cardiomyopathy(Cardiomyopathy, basic/clinical(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the
- OE-345 Diagnostic Accuracy of Dual-Source CT Cardiac Imaging in Patients with Coronary Artery Disease(CT/DSA(02)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-138 Endothelin-1 Increases L-type Ca Current via an Activation of Ca/calmodulin-Dependent Protein Kinase II in Rat Ventricular Myocytes(Cardiac function, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanes
- Renal Insufficiency is Related to Painless Myocardial Infarction
- FRS-015 Genetic Modulation of Ca^ Uptake Sarcoplasmic Reticulum Does Not Affect Maximal Ca^ Content and Ca^ Leakage in Mouse Myocardium(Cardiac Function "Ventricular Mechanics and Calcium Handling", The 71st Annual Scientific Meeting of the Ja
- Intracellular Mechanism of the Negative Inotropic Effect Induced by α_1-Adrenoceptor Stimulation in Mouse Myocardium
- Use of the Ca-Shortening Curve to Estimate the Myofilament Responsiveness to Ca^ in Tetanized Rat Ventricular Myocytes
- OJ-296 Overexpression of SERCA2a and Sarcolipin Does Not Affect Maximal Ca^ Content and Ca^ Leakage of Sarcoplasmic Reticulum in Mouse Myocardium(Cardiac function, basic/clinical-2 (M) OJ50,Oral Presentation (Japanese),The 70th Anniversary Annual
- A Directly Measurement of SR Ca^ Content in Mouse Ventricular Muscle : Not Vesicular SR(Cardiac Function, Basic/Clinical 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-404 PKC signaling pathway is involved in negative inotropic effect and decrease in Ca^ sensitivity during α_1-adrenoceptor stimulation in mouse myocardium(Cardiac Function, Basic/Clinical 2 (M) : PJ68)(Poster Session (Japanese))
- Antecedent Thrombolytic Therapy Followed by Planned Rescue PCI for Acute Myocardial Infarction, Compared with Primary PCI
- Pulmonary Embolism and Deep Vein Thrombosis Complicating Acute Aortic Dissection during Medical Treatment
- -0493-EFFECT OF THE LEFT VENTRICULAR HYPERTROPHY ON ATRIAL NATRIURETIC POLYPEPTIDE (ANP) SECRETION
- S-4. ラット腎孟ペースメーカー領域に対するGlivec (STI 571)の効果(ユビキタスペースメーカ, 第49回日本平滑筋学会総会)
- O-4. ラット腎杯尿管標本における蠕動起始部位の検討(第47回日本平滑筋学会総会)
- 24. ラット腎孟尿管標本における平滑筋細胞Ca^動態の観察
- 3 Effect of valsartan administration in Japanese women with hypertension and cardiovascular diseases : Subanalysis results by gender from the Jikei Heart Study(Late Breaking Clinical Trials II,Special Program,The 72nd Annual Scientific Meeting of the Japa
- 2 Effect of valsartan in Japanese population with hypertension alone and coronary heart disease : Results from the Jikei Heart Study(Late Breaking Clinical Trials II,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-385 Risk Factor of the Thrombogenicity Related to Catheter Ablation for Atrial Fibrillation(Arrhythmia, therapy(04)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-362 Results of 10 Bare Metal Stents Benchmark Test(Coronary revascularization, PCI-16 (IHD) PJ61,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 1 Long-term Follow-up Results of Ca Antagonist Therapy in Vasospastic Angina Pectoris(How Long Should We Treat the Patients with Vasospastic Angina with Calcium Channel Blockers?,Roundtable Discussion 8 (RT8) (IHD),The 70th Anniversary Annual Scientific M
- PE-435 Impact of Renal Function on B-type Natriuretic Peptide and Cardiac Function in Essential Hypertensive Patients(Hypertension, clinical(05)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 生理機能調節・病態における細胞内Mg濃度変動とナトリウム-マグネシウム交換輸送機構の役割
- Lack of Association between T^→C Mutation in the 5'-Flanking Region of the Endothelial Nitric Oxide Synthase Gene and Essential Hypertension
- PE-014 Abnormal Heart Rate Variability Predicts Future Cardiovascular Events in Patients with Normal Heart and Structural Heart Disease(PE003,Autonomic Nervous System (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulat
- DPJ-037 Feasibility and Safety on Alternative Site Pacing in Right Ventricle(DPJ07,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 2 (A),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-385 Efficacy of Post-stress Early Diastolic Filling Rate Derived from ECG-gated Myocardial Perfusion SPECT to Identify Severe Coronary Artery Disease(OE65,Nuclear Cardiology (Coronary, Myocardium) 1 (I),Oral Presentation (English),The 73rd Annual Scien
- 第1回日本・カナダ合同生理学会に参加して
- 3 Further Cinical Progress of ANP and BNP in the Treatment of Heart Failure(Peptide Hormones in Cardiovascular Diseases,Topic 4 (TP-4) (H),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-566 Retrievable Inferior Vena Cava Filter is Safe and Effective for Prevention of Pulmonary Embolism in Patients with Deep Vein Thrombosis(Pulmonary circulation(02)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulati
- PJ-272 0.010-inch-Guidewire System is Useful for Treatment of Chronic Total Occlusion(PJ046,Coronary Revascularization, PCI (New Devices/New Technology) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Socie
- Effects of Atorvastatin on Nuclear Magnetic Resonance-Defined Lipoprotein Subclasses and Inflammatory Markers in Patients with Hypercholesterolemia
- PE-353 Effects of Rousvastatin on ApoB-containing Lipoproteins Including Small Dense LDL Metabolism in Hypercholesterolemic Patients : A Stable Isotope Study(Lipid disorders(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese
- What is an Important Factor for the late Left Ventricular Remodeling? (Old Myocardial Infarction/Remodeling 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Mechanism of Increasing Ca^ Responsiveness by α_1-Adrenoceptor Stimulation in Rat Ventricular Myocytes
- Use of Tetanus to Investigate Myofibrillar Responsiveness to Ca^ in Isolated Mouse Ventricular Myocytes
- EFFECTS OF BETA-ADRENOCEPTOR STIMULATION ON MAXIMAL TENSION AND Ca SENSITIVITY IN TETANIZED FERRET PAPILLARY MUSCLES : Cardiovascular Drugs : 53 Annual Scientific Meeting, Japanese Circulation Society
- 医科学フォーラム第2回講演会
- Calcium Waves in Skinned Cardiac Myocytes Evoked by Two-Photon Excitation Photolysis of Caged Calcium
- 筋細胞内Cα, Mgイオン濃度制御
- Spironolactone decreased mortality rate and myocardial fibrosis, and improved cardiac function after myocardial infarction
- 0290 ROLE OF GASTRIC EMPTYING ON THE BLOOD CONCENTRATION AND ANTIHYPER-TENSIVE EFFECT OF SUSTAINED-RELEASE NIFEDIPINE
- Vasospastic Angina in a Patient With Fabry's Disease who Showed Normal Coronary Angiographic Findings
- PJ-648 Comparison of Outcomes of Hemodialysis Patients after PCI in the BMS Versus in the DES Era(Coronary revascularization, PCI(23)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Continuous ATP Injection on Human Hemodynamics
- Difference in risk factors between acute coronary syndrome and stable angina pectoris in the Japanese : Smoking as a crucial risk factor of acute coronary syndrome
- Pump failure death and sudden cardiac death in patients with cardiac dysfunction : A search for prognostic predictive factors-A long-term follow-up study
- Influence of Low-Grade Inflammation on Plasma B-type Natriuretic Peptide Levels
- PJ-651 Initial and Long-Term Outcomes of Sirolimus-Eluting Stents for Hemodialysis Patients(Coronary revascularization, PCI(23)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Clinical Significance of B-Type Natriuretic Peptide in the Assessment of Untreated Hypertension
- Mitral Regurgitation Disappearance after Cibenzoline Treatment in a Patient with Hypertrophic Obstructive Cardiomyopathy
- Resistant Hypertension in an Aged Woman Presenting with Clinical Features Simulating Ectopic ACTH Syndrome -Response to Spironolactone-
- Prior Treatment with Renin-angiotensin System Blockers Has a Myocardial Protective Effect in Patients with Acute Myocardial Infarction
- Nitrate Tolerance as a Possible Cause of Multidrug-Resistant Coronary Artery Spasm : A Case Report and Its Implications
- Impact of Body Mass Index on Clinical Outcome in Patients Hospitalized With Congestive Heart Failure
- Japanese-Western Consensus Meeting on Biomarkers : Executive Summary
- Contribution of Extracardiac Factors to the Inconsistency Between Plasma B-type Natriuretic Peptide Levels and the Severity of Pulmonary Congestion on Chest X-rays in the Diagnosis of Heart Failure
- Thyroid Function and Risk of Atrial Tachyarrhythmia Occurrence after Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation
- Guidelines for Secondary Prevention of Myocardial Infarction (JCS 2011) : Digest Version
- Do Indices of Coronary Conductance After Reperfusion Reflect the Extent of Salvaged Myocardium?
- Coronary Artery Spasm Discovered in Thorough Examination of Perioperative VT in a 26-year-old Japanese Male.
- The Insulin Sensitizer Pioglitazone Improves the Deterioration of Ischemic Preconditioning in Type 2 Diabetes Mellitus Rats
- Guidelines for Treatment of Acute Heart Failure (JCS 2011) : Digest Version
- Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals : possible involvement of the insulin resistance