Resistant Hypertension in an Aged Woman Presenting with Clinical Features Simulating Ectopic ACTH Syndrome -Response to Spironolactone-
スポンサーリンク
概要
- 論文の詳細を見る
A 91-year-old depressed woman had resistant hypertension despite a triple combination of anti-hypertensives, including a Ca-antagonist, an angiotensin receptor blocker, and a thiazide diuretic at optimal doses. She had hypokalemic metabolic alkalosis, elevated plasma cortisol and ACTH, and elevated urinary cortisol. The high-dose dexamethasone did not suppress the elevated ACTH and cortisol. The addition of spironolactone to her previous medications controlled and normalized hypertension, hypokalemia, and hormonal abnormalities within 4 months. Her blood pressure, serum electrolytes, and the hormonal states remained normalized for more than a year thereafter. Her depressed mental state also improved after spironolactone.
著者
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Harada Eisaku
Division of Cardiology, Kumamoto Aging Research Institute
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Morikawa Yoshinobu
Division Of Cardiology Kumamoto Aging Research Institute
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Yoshimura Michihiro
Division Of Cardiology Department Of Internal Medicine Jikei University School Of Medicine
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Yasue Hirofumi
Division Of Cardilogy Kumamoto University School Of Medicine
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Mizuno Yuji
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
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Yasue Hirofumi
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute
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Saito Yoshihiko
The First Department of Internal Medicine, Nara Medical School
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Semba Fumie
Semba Medical Clinic
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Nakagawa Hitoshi
The First Department of Internal Medicine, Nara Medical School
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