Nitrate Tolerance as a Possible Cause of Multidrug-Resistant Coronary Artery Spasm : A Case Report and Its Implications
スポンサーリンク
概要
- 論文の詳細を見る
Coronary spasm can usually be controlled by administration of Ca antagonists. However, there are some cases of coronary spasm whose attacks cannot be controlled even with large doses of Ca antagonist and/or its combination with nitrates. Here we describe the case of a 41-year-old man whose attacks of coronary spasm were resistant to the combined administration of nitrates, Ca antagonists, and a statin. The attacks were alleviated and disappeared after withdrawal of nitrates and recurred after readministration of a nitroglycerin patch. The involvement of nitrate tolerance in the pathogenesis of multidrug resistant coronary spasm was revealed and its implication discussed.
著者
-
Harada Eisaku
Division of Cardiology, Kumamoto Aging Research Institute
-
Morikawa Yoshinobu
Division Of Cardiology Kumamoto Aging Research Institute
-
Yoshimura Michihiro
Division Of Cardiology Department Of Internal Medicine Jikei University School Of Medicine
-
Yasue Hirofumi
Division Of Cardilogy Kumamoto University School Of Medicine
-
Kuboyama Osamu
Division of Cardiology, Cardiovascular Center, Tsuchiura Kyodo Hospital
-
Mizuno Yuji
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
-
Morikawa Yoshinobu
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute
-
Harada Eisaku
Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute
関連論文
- PJ-781 A "Point of no return" in Atrial Fibrillation-induced Cardiomyopathy(Arrhythmia, diagnosis / Pathophysiology / EPS(16)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Long-Term Follow-up of Neointimal Coverage of Sirolimus-Eluting Stents : Evaluation With Optical Coherence Tomography
- PE-463 Similarities and Differences between Coronary Spasm and Atherosclerosis : a Coronary Angiographic Study(PE078,Angina Pectoris (Clinical) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-255 N-terminal Pro-BNP is more Closely Correlated with Ejection Fractioin and Glomerular Filtration Rate in Patients with Renal Dysfunction than BNP(PE043,Heart Failure (Biomarker) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of Th
- PE-083 Morphological Features of Coronary Arteries in Patients with Diabetes Mellitus : Study Using Intravascular Optical Coherence Tomography(PE014,Intravascular Imagings (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Cir
- OJ-179 Aldosterone Production Level is Strongly Predicted by Absolute Value of Difference of Subcutaneous and Visceral Fat Area in Essential Hypertension(OJ30,Hypertension, Clinical (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of Th
- OJ-134 Aldosterone, but Not Angiotensin II, Reduces Angiotensin Converting Enzyme 2 Gene Expression Levels in Cultured Neonatal Rat Cardiomyocytes(OJ23,Hypertension, Basic (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- 2 The Effects of Statin for Coronary Artery Spasm(Recent Progress in the Management of Vasospastic Angina,Meet the Expert 6 (ME-6) (IHD),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Aldosterone, but Not Angiotensin II, Reduces Angiotensin Converting Enzyme 2 Gene Expression Levels in Cultured Neonatal Rat Cardiomyocytes
- PJ-321 Clinical Factors Affecting Serum Potassium Concentration(Heart failure, clinical(16)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-343 Effects of the Infusion of A-type Natriuretic Hormone (ANP) on the Activity of Hypothalamic-Pitultary-Adrenal Axis in Patients With Heart Failure(Heart failure, clinical(10)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japan
- PE-239 The Effects of Statins on Coronary Artery Spasm (S-CAST Study)(Acute coronary syndrome, basic/clinical(04)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-083 Coronary Spasm Preferentially Occurs at the Branching Site : possible role of impaired endothelial NO activity due to low shear tress(Angina pectoris, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japa
- 2 Spastic Angina Genetic (SAGE) Study(Plenary Session 7 (PL-7) (M) Genomic Approaches to Cardiovascular Diseases : Present and Future,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Coronary Spasm and hs-CRP(Letter to the Editor)
- Coronary Spasm is Associated With Chronic Low-Grade Inflammation
- OJ-179 Aldosterone Production Level is Strongly Predicted by Absolute Value of Difference of Subcutaneous and Visceral Fat Area in Essential Hypertension(OJ30,Hypertension, Clinical (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of Th
- OJ-179 Aldosterone Production Level is Strongly Predicted by Absolute Value of Difference of Subcutaneous and Visceral Fat Area in Essential Hypertension(OJ30,Hypertension, Clinical (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of Th
- PE-343 Effects of the Infusion of A-type Natriuretic Hormone (ANP) on the Activity of Hypothalamic-Pitultary-Adrenal Axis in Patients With Heart Failure(Heart failure, clinical(10)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japan
- OE-083 Coronary Spasm Preferentially Occurs at the Branching Site : possible role of impaired endothelial NO activity due to low shear tress(Angina pectoris, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japa
- OE-306 Pivotal Role of Soluble Flt-1 in Renal Dysfunction-Induced Aggravation of Atherosclerosis of ApoE-KO Mice(OE52,Kidney/Renal Circulation/CKD 2 (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-185 Clinical Predictors of Uncovered Stent Struts after Sirolimus-Eluting Stent Implantation : Optical Coherence Tomography Study(OE32,Coronary Revascularization, PCI (Restenosis/Others) 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Me
- FRS-113 Comparison of Neointimal Growth in Chronic Phase between Paclitaxel and Sirolimus-eluting Stent Implantation : Optical Coherence Tomography Study(FRS23,Clinical Evidence of DES Era (1) (IHD),Featured Research Session (English),The 73rd Annual Scie
- FRS-026 Diagnostic Accuracy of Dual-source Computed Tomography on the Characterization of Coronary Atherosclerotic Plaque : Comparison with Intravascular Optical Coherence Tomography(FRS6,Non-invasive Assessment of Coronary Lesions (I),Featured Research S
- 4 Optical Coherence Tomography Study of Neointimal Coverage after Silorimus-eluting Stent Implantation : Implication for the Long-term Dual Antiplatelet Therapy(Current Status and Future Perspective of Antiplatelet Therapy in Management of Coronary Artery
- Progression of Non-Culprit Coronary Artery Atherosclerosis After Acute Myocardial Infarction in Comparison with Stable Angina Pectoris
- PJ-710 Optical Coherence Tomography Assessment of Coronary Artery Structure in Patients with Coronary Spastic Angina(Intravascular endoscopy / Intravascular ultrasound(07)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circ
- PJ-351 Cardiac Diffusion-weighted MRI Compensates for T2-weighted Imaging in the Detection of Infarct-related Myocardial Edema(MRI/MRA(03)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-346 Late Neointimal Growth after Silorimus-Eluting Stent Implantation : Optical Coherence Tomography study(Intravascular endoscopy/Intravascular ultrasound(03)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation So
- OE-377 Papillary Muscle Gadolinium Late Enhancement : Frequency and Relationship with Mitral Regurgitation(MRI/MRA(01)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-302 Soluble Fms-like Tyrosine Kinase 1, a Predictive Biomarker of Acute Severe Heart Failure in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical(diagnosis/treatment)(02)(IHD),Oral Presentation(English),The 72nd Annual Sci
- Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats
- Infiltration of Macrophages Through the Atrial Endocardium of Inflammation-Induced Rats : Contribution of Fractalkine
- PJ-751 Impact of Smoking on Restenosis after Percutaneous Coronary Intervention (PCI) with Bare Metal Stents (BMS)(PJ126,Smoking/Alcohol/Life Style (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-507 Association of QTc Prolongation with Low Blood pH in Diabetic Patients with Acute Heart Failure Status(PJ085,Heart Failure (Pathophysiology) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-479 Additional Evaluation for Ischemia is Required to Perform CAG after MSCT(PJ081,CT/MRI (Coronary/Vascular) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-435 Promotion of Macrophage Infiltration and Interstitial Fibrosis in Diabetic Rat Atria(PJ073,Arrhythmia, Others (Basic) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-167 Factors for Long Term Hospitalization with Chronic Heart Failure(PJ028,Cardiovascular Pharmacology (Basic), Cost-health care system/DPC/Laws (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-081 Relationship between Delayed Enhancement of Cardiac MRI and Clinical Features in Hypertrophic Cardiomyopathy(PJ014,Cardiomyopathy/Hypertrophy (Clinical) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- PE-332 One-Year Angiographic Outcome after Balloon Dilation of In-Stent Restenosis Inside Sirolimus-Eluting Stent(PE056,Coronary Revascularization, PCI (Restenosis/Others) 3 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese
- PE-256 Regional Differences in Removal of Atrial Natriuretic Polypeptide in the Human Lungs(PE043,Heart Failure (Biomarker) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008) : Digest Version
- Coronary artery spasm-Clinical features, diagnosis, pathogenesis, and treatment
- Simultaneous Elevation of the Levels of Circulating Monocyte Chemoattractant Protein-1 and Tissue Factor in Acute Coronary Syndromes
- IS040 Positive association between essential hypertension and Glu298Asp polymorphism in the endothelial nitric oxide synthase gene
- PE-008 Infiltration of Macrophages through Atrial Endocardium by Upregulation of Fractalkine Expression in Inflammation-induced Rats.(Arrhythmia, basic(03)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-007 Accumulation of Advanced Glycation End Products in Human Fibrillated Atria(Arrhythmia, basic(03)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-148 Involvement of SPARC Protein Expression in Interstitial Fibrosis in Human Fibrillated Atria(Arrhythmia, basic(01)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Decreased Renal Function as an Independent Predictor of Re-Hospitalization for Congestive Heart Failure
- PJ-851 Abnormal Heart Rate Variability Predicts Future Cardiovascular Events in Patients with Structurally Normal Heart(ECG / Body surface potential mapping / Holter(07)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circul
- OE-218 Sonazoid Contrast Renal Ultrasonography Enables Differentiation between Cortical and Medullary Microcirculation(Kidney/Renal circulation(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-091 Soluble Fms-like Tyrosine Kinase 1 (sFlt-1), a Key Molecule Involving in Pathophysiology in Cardio-Renal Connection(Renal Dysfunction and Cardiovascular Disease(H),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circul
- 3 Tissue Characterization of Coronary Artery in Patients with Coronary Spastic Angina by Intravascular Optical Coherence Tomography(Symposium 2 (SY-02) (IHD) Coronary Spasm Revisited,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circu
- PJ-521 Outcome of Double-stenting or Single-stenting Techniques for Bifurcation Lesions Evaluated by Anatomic Morphologies Using Intravascular Ultrasound(Coronary revascularization, PCI-19 (IHD) PJ88,Poster Session (Japanese),The 70th Anniversary Annual S
- DPE-069 Angiotensin II Type 1 Receptor Blockade Rescued the Mouse Model of Dilated Cardiomyopathy from Sudden Cardiac Death(DPE12,Cardiomyopathy/Hypertrophy (Basic) (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- Inhibition of the Renin-Angiotensin System Prevents Re-Hospitalization of Heart Failure Patients With Preserved Ejection Fraction
- PE-038 Decreased Ca^ Sensitivity of the Myofilament is Critical for the Development of Cardiac Dysfunction in Mouse Model of Dilated Cardiomyopathy(Cardiomyopathy, basic/clinical(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the
- OE-345 Diagnostic Accuracy of Dual-Source CT Cardiac Imaging in Patients with Coronary Artery Disease(CT/DSA(02)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-138 Endothelin-1 Increases L-type Ca Current via an Activation of Ca/calmodulin-Dependent Protein Kinase II in Rat Ventricular Myocytes(Cardiac function, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanes
- -0493-EFFECT OF THE LEFT VENTRICULAR HYPERTROPHY ON ATRIAL NATRIURETIC POLYPEPTIDE (ANP) SECRETION
- 3 Effect of valsartan administration in Japanese women with hypertension and cardiovascular diseases : Subanalysis results by gender from the Jikei Heart Study(Late Breaking Clinical Trials II,Special Program,The 72nd Annual Scientific Meeting of the Japa
- 2 Effect of valsartan in Japanese population with hypertension alone and coronary heart disease : Results from the Jikei Heart Study(Late Breaking Clinical Trials II,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-385 Risk Factor of the Thrombogenicity Related to Catheter Ablation for Atrial Fibrillation(Arrhythmia, therapy(04)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-435 Impact of Renal Function on B-type Natriuretic Peptide and Cardiac Function in Essential Hypertensive Patients(Hypertension, clinical(05)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Lack of Association between T^→C Mutation in the 5'-Flanking Region of the Endothelial Nitric Oxide Synthase Gene and Essential Hypertension
- Reduction in Gene Expression of Angiotensin Converting Enzyme 2 by Aldosterone in Neonatal Rat Cardiomyocytes(Heart Failure, Clinical 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-014 Abnormal Heart Rate Variability Predicts Future Cardiovascular Events in Patients with Normal Heart and Structural Heart Disease(PE003,Autonomic Nervous System (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulat
- DPJ-037 Feasibility and Safety on Alternative Site Pacing in Right Ventricle(DPJ07,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 2 (A),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-141 Low-grade Inflammation in Smokers and Effects of Smoking Cessation(Smoking-2 (H) PJ24,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Low-Grade Inflammation, Thrombogenicity, and Atherogenic Lipid Profile in Cigarette Smokers
- OE-385 Efficacy of Post-stress Early Diastolic Filling Rate Derived from ECG-gated Myocardial Perfusion SPECT to Identify Severe Coronary Artery Disease(OE65,Nuclear Cardiology (Coronary, Myocardium) 1 (I),Oral Presentation (English),The 73rd Annual Scien
- Elevation of Plasma Levels of ACTH and Aldosterone in Patients with Essential Hypertension; Possible Roles in Low Renin Hypertension
- Activation of Proopiomelanocortin Gene Expression in Failing Human Heart
- Possible Cardioprotective Effect of Dehydroepiandrosterone Produced in the Human Heart
- Aldosterone Induces Angiotensin-Converting-Enzyme Gene Expression through Both Mineralcorticoid -and Glucocorticoid- Receptors in Cultured Neonatal Rat Cardiocytes
- Inhibitory Effect of Natriuretic Peptides on Aldosterone Synthase Gene Expression in Cultured Neonatal Rat Cardiocytes
- PE-093 A HMG-CoA Reductase Inhibitor is a Potential Novel Therapic Agent for Coronary Spasm(Acute coronary syndrome, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-329 Nocturnal Fall Level of Blood Pressure is Strongly Associated with Salt Sensitivity Partially via Renal Dysfunction in Patients with Hypertension(Hypertension, clinical-03, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-594 How Long Calcium Antagonists Should be Administered in Patients with Coronary Artery Spasm?(Angina pectoris, basic/clinical-5 (IHD) PJ100,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-487 Nocturnal Fall Level of Blood Pressure Predicts Salt Sensitivity in Patients with Hypertension(Hypertension, clinical-5 (H) PE82,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 3 Further Cinical Progress of ANP and BNP in the Treatment of Heart Failure(Peptide Hormones in Cardiovascular Diseases,Topic 4 (TP-4) (H),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-566 Retrievable Inferior Vena Cava Filter is Safe and Effective for Prevention of Pulmonary Embolism in Patients with Deep Vein Thrombosis(Pulmonary circulation(02)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulati
- PJ-272 0.010-inch-Guidewire System is Useful for Treatment of Chronic Total Occlusion(PJ046,Coronary Revascularization, PCI (New Devices/New Technology) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Socie
- Circadian Blood Pressure Profile and Its Response to Ca-Antagonists in Patients with Coronary Spastic Angina
- Effects of Atorvastatin on Nuclear Magnetic Resonance-Defined Lipoprotein Subclasses and Inflammatory Markers in Patients with Hypercholesterolemia
- PE-353 Effects of Rousvastatin on ApoB-containing Lipoproteins Including Small Dense LDL Metabolism in Hypercholesterolemic Patients : A Stable Isotope Study(Lipid disorders(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese
- PJ-648 Comparison of Outcomes of Hemodialysis Patients after PCI in the BMS Versus in the DES Era(Coronary revascularization, PCI(23)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Difference in risk factors between acute coronary syndrome and stable angina pectoris in the Japanese : Smoking as a crucial risk factor of acute coronary syndrome
- Pump failure death and sudden cardiac death in patients with cardiac dysfunction : A search for prognostic predictive factors-A long-term follow-up study
- Influence of Low-Grade Inflammation on Plasma B-type Natriuretic Peptide Levels
- PJ-651 Initial and Long-Term Outcomes of Sirolimus-Eluting Stents for Hemodialysis Patients(Coronary revascularization, PCI(23)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Clinical Significance of B-Type Natriuretic Peptide in the Assessment of Untreated Hypertension
- A-type Natriuretic Hormone Inhibits the Over-activation of the Hypothalamic-Pituitary-System in Patients with Heart Failure : Anti-Stress Effects of ANP(Heart Failure, Clinical 13 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society
- Resistant Hypertension in an Aged Woman Presenting with Clinical Features Simulating Ectopic ACTH Syndrome -Response to Spironolactone-
- Nitrate Tolerance as a Possible Cause of Multidrug-Resistant Coronary Artery Spasm : A Case Report and Its Implications
- Impact of Body Mass Index on Clinical Outcome in Patients Hospitalized With Congestive Heart Failure
- Japanese-Western Consensus Meeting on Biomarkers : Executive Summary
- Contribution of Extracardiac Factors to the Inconsistency Between Plasma B-type Natriuretic Peptide Levels and the Severity of Pulmonary Congestion on Chest X-rays in the Diagnosis of Heart Failure
- Alcohol Flushing and Positive Ethanol Patch Test in Patients with Coronary Spastic Angina: Possible Role of Aldehyde Dehydrogenase 2 Polymorphisms
- Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals : possible involvement of the insulin resistance