A Case of Adolescent Hyperlipoproteinemia with Xanthoma and Acute Pancreatitis, Associated with Decreased Activities of Lipoprotein Lipase and Hepatic Triglyceride Lipase
スポンサーリンク
概要
- 論文の詳細を見る
Lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) enhance the hydrolysis of triglycerides (TG) transported by chylomicron (CM) and very-low-density lipoprotein (VLDL). We report a case of severe hyperchylomicronemia with high levels of remnant lipoprotein and total cholesterol (T-Chol) in a 15-year-old boy. Precise examination of the lipid profile showed decreased activities of both LPL and HTGL, although the protein mass for LPL and HTGL were maintained. In addition, bezafibrate treatment effectively ameliorated hypertriglyceridemia in this case. This is the first case of hyperchylomicronemia with decreased activities and unaffected protein masses for both LPL and HTGL, without overt immuno-dysfunction.
著者
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Maeda Norikazu
Department Of Metabolic Medicine Graduate School Of Medicine
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OKITA Kohei
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
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Kozawa Junji
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Osaka University
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Shimomura Iichiro
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Osaka University
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Ishigami Masato
Division of Health Sciences, Osaka University Graduate School of Medicine
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Shirai Kohji
Department Of Clinical Laboratory Medicine Sakura Hospital School Of Medicine Toho University
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Funahashi Tohru
Department Of Cardiovascular Surgery National Cerebral And Cardiovascular Center
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Fujita Koichi
Department Of Gastroenterology Yodogawa Christian Hospital
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Nakamura Tadashi
Department Of Anesthesia Junwakai Memorial Hospital
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Iwahashi Hiromi
Department Of Gastroenterology And Hepatology Osaka University Graduate School Of Medicine
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Kihara Shinji
Department Of Biomedical Informatics Graduate School Of Medicine Osaka University
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Murano Kakeyoshi
Research Development Center, Sakura Hospital, Medical Center, Toho University
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Omura Motoko
Omura Internal Medicine and Cardiology Clinic
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Yamamura Taku
Division of Health Sciences, Graduate School of Medicine, Osaka University
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Shirai Kohji
Department of Internal Medicine, Sakura Hospital, Medical Center, Toho University
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Ishigami Masato
Division of Health Sciences, Graduate School of Medicine, Osaka University
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