Angioscopic Study of Silent Plaque Disruption in Nonischemic Related Coronary Artery in Patients With Stable Ischemic Heart Disease

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概要

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• Plaque disruption, which may be associated with some coronary risk factors, plays a key role in the development of acute coronary syndromes and progression of atherosclerosis. However, the clinical profile of asymptomatic plaque disruption in stable ischemic heart disease has not been well evaluated. The aim of the present study was to investigate the frequency and determinants of silent plaque disruption (SPD) in patients with stable ischemic heart disease using coronary angioscopy. Forty-one patients with stable angina or old myocardial infarction (OMI) without any complaints within 3 months were included in the present study. Angioscopy was successfully performed through 49 nonischemic related coronary arteries. The presence of SPD and coronary risk factors were recorded. Silent plaque disruption was found in 12 patients with stable ischemic heart disease (12/41, 29.3%), and the frequency of SPD in nonischemic related coronary arteries was 26.5% (13/49). A significantly higher frequency of SPD was noted in yellow plaques than in white plaques (35.3% versus 6.7%, P = 0.043). Overall, the independent clinical risk factors of SPD in nonischemic related coronary arteries were diabetes mellitus (P = 0.018; OR, 18.8209; 95% CI, 1.6525 to 214.3523) and hypertension (P = 0.0313; OR, 6.6485; 95% CI, 1.1850 to 37.3019). These results suggest silent plaque disruption was commonly observed in nonischemic related coronary arteries in patients with stable ischemic heart disease and its determinants were diabetes mellitus and hypertension.

著者

• Mizuno Kyoichi

  First Department Of Internal Medicine Nippon Medical School

• Yasutake Masahiro

  First Department of Internal Medicine, Nippon Medical School

• Takano Hitoshi

  First Department of Internal Medicine, Nippon Medical School

• Takagi Gen

  First Department of Internal Medicine, Nippon Medical School

• Aoki Satoshi

  First Department of Internal Medicine, Nippon Medical School

• Kato Koji

  First Department Of Internal Medicine Nippon Medical School

• Yamamoto Masatoshi

  Department Of Applied Biology Kyoto Institute Of Technology

• Asai Kuniya

  First Department Of Internal Medicine Nippon Medical School

• YAMAMOTO HIDEO

  First Department of Surgery, Nagoya University School of Medicine

• Inami Shigenobu

  First Department of Medicine, Nippon Medical School

• Ohba Takayoshi

  Department of Cardiology, Cardiovascular Center, Nippon Medical School Chiba-Hokusoh Hospital

• Ohba Takayoshi

  Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School

• Wang Zuoyan

  First Department of Internal Medicine, Nippon Medical School

• Kirinoki Sonoko

  First Department of Internal Medicine, Nippon Medical School

• Takano Masamichi

  First Department of Internal Medicine, Nippon Medical School

• Yamamoto Hideo

  First Department of Internal Medicine, Nippon Medical School

• Inami Shigenobu

  First Department of Internal Medicine, Nippon Medical School

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