Genotype frequencies of the ABCC11 gene in 2000–3000-year-old human bones from the Epi-Jomon and Jomon sites in Hokkaido, Japan
スポンサーリンク
概要
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In order to investigate further the allele frequencies of the adenosine triphosphate-binding cassette sub-family C11 (ABCC11) gene, which determines earwax phenotypes, among ancient populations in Hokkaido, Japan, the single-nucleotide polymorphism and the 27 bp deletion in the ABCC11 gene were analyzed in ancient DNA extracted from 38 Epi-Jomon, 24 Jomon, and one Satsumon specimens excavated from various archaeological sites in Hokkaido. Of the specimens analyzed, 10 Epi-Jomon and three Jomon specimens were successfully genotyped. One homozygote for the 27 bp deletion was found first in one Epi-Jomon specimen. Including previously reported data on the Okhotsk people and modern Ainu, exact tests of population differentiation showed that allele frequencies of the ABCC11 gene between the Jomon people and Ainu were statistically significantly different, whereas those between the Jomon and Epi-Jomon people and those between the Epi-Jomon people and Ainu were not significantly different. This result indicates that the Ainu, direct descendants of the Jomon people, were genetically affected by populations who possessed high frequencies of allele A (recessive dry allele) of the ABCC11 locus after the Jomon period.
著者
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Amano Tetsuya
Hokkaido University Museum, Sapporo
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ISHIDA HAJIME
Faculty of Medicine, University of the Ryukyus, Nishihara
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DODO Yukio
Tohoku University School of Medicine
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MATSUMURA Hirofumi
Sapporo Medical University
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Kazuta Hisako
Graduate School Of Science Hokkaido University
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Sato Takehiro
Graduate School Of Science Hokkaido University
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Masuda Ryuichi
Graduate School Of Science Hokkaido University
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Amano Tetsuya
Hokkaido University Museum Hokkaido University
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MASUDA RYUICHI
Graduate School of Science, Hokkaido University, Sapporo
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MATSUMURA HIROFUMI
Sapporo Medical University, Sapporo
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DODO YUKIO
Tohoku University School of Medicine, Sendai
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