噴霧乾燥法による医薬品製剤粒子の設計

概要

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Spray dry technique is one of the useful tools and is widely used for preparing pharmaceutical dosage forms and manufacturing pharmaceutical excipients. Spray drying of particles adds functions to the raw particles, e.g., flowability and compressibility. Other advantages of spray drying technique are to encapsulate drug in polymer matrix (microcapsule) and prepare the composite particle by a simple process. Microcapsule shows the controlled release properties. In developing the drug delivery system, nano-drug carriers are paid recent attention. The spray dry technique can produce composite of nano-drug carrier and sugar alcohol in powder state. When the nano-composite powder is administered, the nano-drug carrier can promptly dissolve by the dissolution of sugar alcohol. The spray drying technique will be used more widely and more frequently in the future as a tool for hybridization of drug with functional materials so as to develop effective drug delivery systems.