Antioxidant and Amine Oxidase Inhibitory Activities of Hydroxyurea

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概要

• 論文の詳細を見る

• Hydroxyurea (HU, NH2CONHOH), or hydroxycarbamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicarbazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.

• 社団法人 日本農芸化学会の論文

著者

• HOU Wen-Chi

  Graduate Institute of Pharmacognosy Science, College of Pharmacy, Taipei Medical University

• LIU Yuh-Hwa

  Division of Gastroenterology, Shin Kong Wu Ho-Su Memorial Hospital

• WU Wen-Chun

  Graduate Institute of Pharmacognosy, Taipei Medical University

• LU Yeh-Lin

  School of Pharmacy, Taipei Medical University

• LAI Ying-Jang

  Department of Food Science, National Kinmen Institute of Technology

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• Taiwanofungus camphoratus Activates Peroxisome Proliferator-Activated Receptors and Induces Hypotriglyceride in Hypercholesterolemic Rats
• Antioxidant and Amine Oxidase Inhibitory Activities of Hydroxyurea
• Effects of Different Types of Yam (Dioscorea alata) Products on the Blood Pressure of Spontaneously Hypertensive Rats
• Antioxidant and Amine Oxidase Inhibitory Activities of Hydroxyurea
• Taiwanofungus camphoratus Activates Peroxisome Proliferator-Activated Receptors and Induces Hypotriglyceride in Hypercholesterolemic Rats
• DPPH Radical Scavenging and Semicarbazide-Sensitive Amine Oxidase Inhibitory and Cytotoxic Activities of Taiwanofungus camphoratus (Chang-Chih)
• Antihypertensive Activities of a Solid-State Culture of Taiwanofungus camphoratus (Chang-Chih) in Spontaneously Hypertensive Rats
• Effects of Different Types of Yam (Dioscorea alata) Products on the Blood Pressure of Spontaneously Hypertensive Rats

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