Taiwanofungus camphoratus Activates Peroxisome Proliferator-Activated Receptors and Induces Hypotriglyceride in Hypercholesterolemic Rats

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概要

• 論文の詳細を見る

• Taiwanofungus camphoratus (T. camphoratus), a fungus and a Taiwan-specific, well-known traditional Chinese medicine, has long been used to treat diarrhea, hypertension, itchy skin, and liver cancer. To gain a large amount of T. camphoratus, several culture techniques have been developed, including solid-state culture and liquid-state fermentation. Peroxisome proliferator-activated receptor gamma (PPARγ) has been described as a hypoglycemic agent that increases insulin sensitivity in peripheral tissues and results in reduced blood glucose, insulin, and triglyceride levels in insulin-resistant animals and in type-2 (non-insulin-dependent) diabetic patients. In this study, we investigate the possibility that T. camphoratus might activate PPARγ in vitro and hypolipidemic activity in vivo. The results show that an aqueous extract of the wild fruiting bodies of T. camphoratus was able to increase the PPARγ activity in cells transfected with the PPARγ expression plasmid and the AOx-TK reporter plasmid. Based on the cell experiment, we examined the hypolipidemic effect of wild fruiting bodies (WFT) and a solid-state culture (SST) of T. camphoratus on SD rats fed on a high-cholesterol (HC) diet. The results show that WFT significantly decreased the serum triglyceride level, but could not affect the cholesterol level. SST only slightly decreased the serum triglyceride level. In addition, both WFT and SST significantly decreased the serum alanine transaminase (ALT) level and protected against the liver damage induced by the HC diet from the results of a histological examination. These results suggest that T. camphoratus might contain PPARγ ligands and result in a hypotriglyceridemic effect, and that it also exhibits a liver protective activity.

• 社団法人 日本農芸化学会の論文

著者

• SUK Fat-Moon

  Department of Internal Medicine, Taipei Medical University Hospital & Wan-Fang Hospital

• LIN Shyr-Yi

  Department of Primary Care Medicine, Taipei Medical University Hospital

• CHEN Chien-Ho

  School of Medical Laboratory Science & Biotechnology, College of Medicine, Taipei Medical University

• YEN Shish-Jung

  School of Medical Laboratory Science & Biotechnology, College of Medicine, Taipei Medical University

• SU Ching-Hua

  Graduate Institutes of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medica

• LIU Der-Zen

  Graduate Institutes of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medica

• HOU Wen-Chi

  Graduate Institute of Pharmacognosy Science, College of Pharmacy, Taipei Medical University

• HUNG Ling-Fang

  School of Medical Laboratory Science & Biotechnology, College of Medicine, Taipei Medical University

• LIN Pei-Jung

  School of Medical Laboratory Science & Biotechnology, College of Medicine, Taipei Medical University

• LIANG Yu-Chih

  School of Medical Laboratory Science & Biotechnology, College of Medicine, Taipei Medical University

関連論文

• Antihypertensive Activities of a Solid-State Culture of Taiwanofungus camphoratus (Chang-Chih) in Spontaneously Hypertensive Rats
• DPPH Radical Scavenging and Semicarbazide-Sensitive Amine Oxidase Inhibitory and Cytotoxic Activities of Taiwanofungus camphoratus (Chang-Chih)
• Taiwanofungus camphoratus Activates Peroxisome Proliferator-Activated Receptors and Induces Hypotriglyceride in Hypercholesterolemic Rats
• Improving Effects of Epigallocatechin-3-Gallate on Hemorheological Abnormalities of Aging Guinea Pigs
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• Antioxidant and Amine Oxidase Inhibitory Activities of Hydroxyurea
• Taiwanofungus camphoratus Activates Peroxisome Proliferator-Activated Receptors and Induces Hypotriglyceride in Hypercholesterolemic Rats
• Evaluation of Multi-Target and Single-Target Liposomal Drugs for the Treatment of Gastric Cancer
• DPPH Radical Scavenging and Semicarbazide-Sensitive Amine Oxidase Inhibitory and Cytotoxic Activities of Taiwanofungus camphoratus (Chang-Chih)
• Antihypertensive Activities of a Solid-State Culture of Taiwanofungus camphoratus (Chang-Chih) in Spontaneously Hypertensive Rats
• Evaluation of Multi-Target and Single-Target Liposomal Drugs for the Treatment of Gastric Cancer
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