Novel Etiological and Therapeutic Strategies for Neurodiseases: Epigenetic Understanding of Gene–Environment Interactions
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概要
- 論文の詳細を見る
Epigenetics is a mechanism that regulates gene expression not depending on the underlying DNA sequence, but on the chemical modifications of DNA and histone proteins. Defects in the factors involved in epigenetic regulation cause congenital neurodevelopmental diseases, and thus, epigenetic regulation is essential for normal brain development. Besides these intrinsic defects, it is becoming increasingly apparent that extrinsic factors, such as insufficient nutrition, psychiatric drugs, and mental stress, also alter epigenetic regulation. Therefore, environmental factors may lead to “acquired” neurodevelopmental disorders through the failure of epigenetic regulation. Epigenetics is a biological key to understand the gene–environment interactions in neurodevelopmental disorders. As the mechanism is reversible, its comprehensive understanding will result in the development of new therapies for these disorders.
- 社団法人 日本薬理学会の論文
著者
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KUBOTA Takeo
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Nati
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Kubota Takeo
Department Of Epigenetics Medicine Interdisciplinary Graduate School Of Medicine And Engineering Uni
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NAGAI Kaoru
Department of Epigenetic Medicine, Interdisciplinary Graduate School of Medicine and Engineering, Un
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Hirasawa Takae
Department Of Epigenetic Medicine Interdisciplinary Graduate School Of Medicine And Engineering Univ
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Nagai Kaoru
Department Of Applied Biological Chemistry College Of Agriculture Osaka Prefecture University
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Miyake Kunio
Department of Epigenetics Medicine, Interdisciplinary Graduate School of Medicine and Engineering, U
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Koide Tsuyoshi
Mouse Genomics Resource Laboratory, National Institute of Genetics, Japan
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Koide Tsuyoshi
Mouse Genomics Resource Laboratory National Institute Of Genetics
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Miyake Kunio
Department Of Epigenetics Medicine Interdisciplinary Graduate School Of Medicine And Engineering Uni
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Hirasawa Takae
Department Of Epigenetics Medicine Interdisciplinary Graduate School Of Medicine And Engineering Uni
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Kubota Takeo
Department Of Epigenetic Medicine Interdisciplinary Graduate School Of Medicine And Engineering University Of Yamanashi
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Nagai Kaoru
Department of Epigenetics Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
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Kubota Takeo
Department of Epigenetics Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
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Miyake Kunio
Department of Epigenetics Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
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