Malignant Leydig Cell Tumor with Spindle-Shaped Cells in a Male CD-1 Mouse
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概要
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Leydig cell tumors with spindle-shaped cells are very rare in humans and animals. We report that an 84-week-old male CD-1 mouse had a malignant Leydig cell tumor characterized by proliferation of oval to spindle-shaped cells with or without fat deposition, and with a storiform pattern. These cells were immunopositive for inhibin and S-100, and negative for the androgen receptor, thereby suggesting that they may have differentiated from Leydig cells. This differentiation from Leydig cells was further confirmed by the immunopositivity of these cells for nestin and α-smooth muscle actin, both of which are known to be expressed in the stem/progenitor cells that differentiate into Leydig cells. These findings suggest that the tumor is most probably a malignant spindle-cell-type Leydig cell tumor.
著者
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Kuwahara Maki
Laboratory Of Pathology Toxicology Division Chemistry Division Institute Of Environmental Toxicology
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YOSHIDA Toshinori
Laboratory of Pathology, Institute of Environmental Toxicology
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TAKAHASHI Naofumi
Laboratory of Pathology, Institute of Environmental Toxicology
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CHIBA Yuko
Laboratory of Pathology, Institute of Environmental Toxicology
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Nakashima Nobuaki
Laboratory Of Pathology Toxicology Division Chemistry Division Institute Of Environmental Toxicology
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Harada Takanori
Laboratory Of Genetic Toxicology The Institute Of Environmental Toxicology
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Ohnuma Aya
Laboratory of Pathology, Toxicology Division, The Institute of Environmental Toxicology
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AKEMA Satoshi
Laboratory of Pathology, Toxicology Division, The Institute of Environmental Toxicology
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KUMAGAI Mutsumi
Laboratory of Pathology, Toxicology Division, The Institute of Environmental Toxicology
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KASHIMOTO Yukiko
Laboratory of Pathology, Toxicology Division, The Institute of Environmental Toxicology
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Ohnuma Aya
Laboratory Of Pathology Toxicology Division The Institute Of Environmental Toxicology
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