Malignant Lymphoma with Severe Infiltrative Growth into Skeletal Muscles in WBN/Kob Rats
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概要
- 論文の詳細を見る
Although spontaneously occurring neoplasms have been reported repeatedly in F344, SD and Wistar rats, which are commonly used strains for routine toxicologic and carcinogenicity studies, there are only a few reports of malignant lymphoma or lymphatic leukemia except for large granular lymphocytic leukemia (LGL) in F344 rats. Malignant lymphoma (lymphosarcoma) is thought to be uncommon in F344 rats. The authors encountered malignant lymphomas of the non-LGL leukemia type with characteristic pathologic features in WBN/Kob rats. The mean age at onset of the disease in all 13 affected rats (8 males and 5 females) was about 60 weeks. Common and characteristic clinical signs were abnormal gait with hind limb paralysis. Macroscopically, the enlargement of the lymph nodes, spleen and liver was slight to moderate. Scattered multiple white-to-gray nodules encompassed the aorta and assumed a bead-like appearance near the thoracic and lumbar vertebrae. Histopathologically, neoplastic proliferative changes were predominant in the bone marrow tissue of the entire body, and many tumor cells infiltrated the spleen and several lymph nodes. The most striking histological features were constant and severe infiltration of tumor cells in the adipose tissue and skeletal muscle adjacent the thoracic and lumber vertebrae. Immunohistochemically, all tumor cells were positive for B-cell markers (PAX-5, CD79a and CD45) and negative for CD3. From the results of immunohistochemistry and morphological examination, these tumors were diagnosed as malignant B-cell lymphomas.
- 日本毒性病理学会の論文
著者
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KODAMA Yasushi
Laboratory of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Hiroshima Int
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OZAKI Kiyokazu
Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University
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SANO Tomoya
Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University
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MATSUURA Tetsuro
Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University
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NARAMA Isao
Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University
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Sano Tomoya
Department Of Pathology Faculty Of Pharmaceutical Sciences Setsunan University
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Narama Isao
Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University
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Kodama Yasushi
Laboratory Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Hiroshima Inter
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Ozaki Kiyokazu
Department Of Pathology Faculty Of Pharmaceutical Sciences Setsunan University
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Ozaki Kiyokazu
Department Of Pathology Faculty Of Pharmaceutical Science Setsunan University
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Matsuura Tetsuro
Department Of Pathology Faculty Of Pharmaceutical Sciences Setsunan University
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Kodama Yasushi
Laboratory Of Molecular And Cellular Pharmacology Department Of Pharmaceutical Sciences Faculty Of P
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