Androgen Modulators from the Roots of Paeonia lactiflora (Paeoniae Radix) Grown and Processed in Nara Prefecture, Japan
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概要
- 論文の詳細を見る
The monoterpene glycoside, 3′-O-galloylpaeoniflorin (1), and four known compounds, 6′-O-galloylalbiflorin (2), pentagalloylglucose (3), 6′-O-benzoylpaeoniflorin (4) and 6′-O-galloylpaeoniflorin (5), were isolated from the roots of Paeonia lactiflora that had been grown and processed in Nara prefecture, Japan, as androgen modulators. Their structures were elucidated based on spectroscopic analysis. Compounds 2 and 3 showed strong androgen receptor (AR) binding activity (IC50 values 33.7 and 4.1 μg/ml, respectively), 1, 4 and 5 showed weak activity (20, 31 and 12% at 120 μg/ml, respectively). However, paeoniflorin (6) and albiflorin (7), the structures of which are related to 1, 2, 4 and 5, showed no activity. These results suggested that both the structure of albiflorin and the galloyl moiety are important for 2 to show strong AR binding activity. Furthermore, compounds 1—5 inhibited growth of an androgen-dependent LNCaP-FGC (prostate cancer cell line), and were indicated to be AR antagonists. Compounds 2 and 3 might be candidates as safe, natural anti-androgens.
- 公益社団法人 日本薬学会の論文
著者
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IWASHITA TAKASHI
Suntory Institute for Bioorganic Research(SUNBOR)
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Iwashita Takashi
Suntory Institute For Bioorganic Research
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Iwashita Takashi
Suntory Inst. For Bioorganic Res. Osaka Jpn
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Washida Kazuto
Nara Prefectural Small and Medium-sized Enterprises Support Corporation, Nara Prefectural Agricultur
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Nomoto Kyosuke
Nara Prefectural Small and Medium-sized Enterprises Support Corporation, Nara Prefectural Agricultur
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Itoh Yoshiyuki
Suntory Institute for Bioorganic Research
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Nomoto Kyosuke
Nara Prefectural Small And Medium-sized Enterprises Support Corporation Nara Prefectural Agricultura
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Washida Kazuto
Nara Prefectural Small And Medium-sized Enterprises Support Corp. Nara Prefectural Agricultural Expe
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