Hemoglobin Replection and the Hematological Response of Anemic Rats to Hemosiderin and Ferrous Sulfate.

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The bioavailability of iron in ferrous sulfate and in hemosiderin, prepared from pig liver in the laboratory, was evaluated in terms of the "hemoglobin regeneration efficiency" (HRE) and hematological indices. The anemia was induced in rats by feeding a casein-based, iron-deficient diet for 1 week and by withdrawal of blood from the retroocular vein. The anemic rats were fed for an additional 6 weeks the iron-deficient diet or the same diet supplemented with ferrous sulfate or hemosiderin at 6, 12, 18, 24 mg iron/kg diet. After 2 weeks, there was no significant difference in the HRE of the anemic rats fed with either hemosiderin or ferrous sulfate diets (31-55% for hemosiderin-fed groups against 28-52% for ferrous sulfate-fed groups). Blood parameters, levels of nonheme iron in the liver and spleen and iron contents in the liver, spleen, kidneys, heart and lungs of the rats fed with the hemosiderin diet were not significantly different than those of the rats fed with the ferrous sulfate diet. No significant difference was observed between the two experimental diets regarding the levels of available iron when assessed by the <I>in vitro</I> digestion method. The results indicated that hemosiderin is a good nutritional source of iron.
社団法人日本食品科学工学会の論文