Donepezil-Induced Adverse Side Effects of Cardiac Rhythm: 2 Cases Report of Atrioventricular Block and Torsade de Pointes
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概要
- 論文の詳細を見る
Acetylcholinesterase inhibitors (AChIs) are widely used in the treatment of mild-to-moderate Alzheimers disease (AD), but their cholinergic effects could generate adverse side effects in the cardiovascular system. This report presents the cases of 2 patients who experienced adverse side effects of cardiac rhythm with QT prolongation caused by Donepezil. Both of them improved to the original rhythm and shortened QT intervals after the discontinuation of Donepezil. The present cases suggest that the cholinergic effects of Donepezil could induce adverse side effects on cardiac rhythm and careful consideration is needed for the patients treated by Donepezil.
著者
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Hiramatsu Yoshihiro
Department Of Cardiology Yufuin Kohseinenkin Hospital
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Koga Shoichi
Department of cardiology, Koga hospital 21
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Tanaka Atsushi
Department Of Cardiology Kariya Toyota General Hospital
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Hiramatsu Yoshihiro
Department of Cardiology, Koga Hospital 21
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